Radio-guided sentinel node detection for gastric cancer

Yuukou Kitagawa, H. Fujii, M. Mukai, T. Kubota, Y. Otani, M. Kitajima

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Background: Radio-guided detection of sentinel nodes (SNs) has been used to predict regional metastases in patients with malignant melanoma and breast cancer. However, the validity of the SN hypothesis is still controversial for gastrointestinal cancers including gastric cancer. The aim of this study was to test the feasibility and accuracy of radio-guided mapping of SNs for gastric cancer. Methods: Some 145 consecutive patients with gastric cancer diagnosed as T1 or T2 and evaluated clinically as N0 were enrolled. Endoscopic injection of technetium-99m-radiolabelled tin colloid was performed before operation and radioactive SNs were identified with a γ probe. Standard radical gastrectomy with lymphadenectomy was performed in all patients and all resected nodes were evaluated by routine histopathological examination. Results: Using radio-guided methods, SNs were detected in 138 (95.2 per cent) of 145 patients. The SN was positive in 22 of 24 patients with lymph node metastasis. The incidence of metastasis in the SNs (7.8 per cent) was significantly higher than that in the non-SNs (0.3 per cent) (P < 0.01). The diagnostic accuracy according to SN status was 98.6 per cent (136 of 138). Conclusion: Radio-guided SN mappíng is an accurate díagnostic procedure for detecting lymph node metastasis in patients with early-stage gastric cancer.

Original languageEnglish
Pages (from-to)604-608
Number of pages5
JournalBritish Journal of Surgery
Volume89
Issue number5
DOIs
Publication statusPublished - 2002

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Radio
Stomach Neoplasms
Neoplasm Metastasis
Lymph Nodes
cyhalothrin
Gastrointestinal Neoplasms
Tin
Technetium
Colloids
Gastrectomy
Lymph Node Excision
Melanoma
Breast Neoplasms
Injections
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Radio-guided sentinel node detection for gastric cancer. / Kitagawa, Yuukou; Fujii, H.; Mukai, M.; Kubota, T.; Otani, Y.; Kitajima, M.

In: British Journal of Surgery, Vol. 89, No. 5, 2002, p. 604-608.

Research output: Contribution to journalArticle

Kitagawa, Y, Fujii, H, Mukai, M, Kubota, T, Otani, Y & Kitajima, M 2002, 'Radio-guided sentinel node detection for gastric cancer', British Journal of Surgery, vol. 89, no. 5, pp. 604-608. https://doi.org/10.1046/j.1365-2168.2002.02065.x
Kitagawa, Yuukou ; Fujii, H. ; Mukai, M. ; Kubota, T. ; Otani, Y. ; Kitajima, M. / Radio-guided sentinel node detection for gastric cancer. In: British Journal of Surgery. 2002 ; Vol. 89, No. 5. pp. 604-608.
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AU - Kitajima, M.

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