Radiographically determined noninvasive adenocarcinoma of the lung: Survival outcomes of Japan Clinical Oncology Group 0201

Hisao Asamura, Tomoyuki Hishida, Kenji Suzuki, Teruaki Koike, Kenichi Nakamura, Masahiko Kusumoto, Kanji Nagai, Hirohito Tada, Tetsuya Mitsudomi, Masahiro Tsuboi, Taro Shibata, Haruhiko Fukuda

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Objective: The study objective was to evaluate the long-term survival of patients with radiographically determined noninvasive lung adenocarcinomas. Methods: A prospective, multi-institutional study on image diagnosis to define early (noninvasive) adenocarcinomas of the lung (Japan Clinical Oncology Group 0201) has shown that a consolidation/tumor ratio on thin-section computed tomography 0.25 or less in cT1a (≤2.0 cm) could be used as a better radiologic criterion for a noninvasive pathology than a consolidation/tumor ratio 0.50 or less in cT1a-b (≤3.0 cm). From the prognostic viewpoints, these criteria were evaluated for 545 patients with adenocarcinoma who underwent lobectomy and lymph node dissection. Results: The subjects consisted of 233 men and 312 women with a median age of 62 years. The median follow-up period among overall patients was 7.1 years (range, 0-8.5 years). The overall and relapse-free 5-year survivals of the overall patients were 90.6% and 84.7%, respectively. When a consolidation/tumor ratio 0.5 or less in cT1a-b was used as a cutoff, the 5-year overall survivals of radiologic noninvasive (121 patients, 22.2%) and invasive (424 patients, 77.8%) adenocarcinomas were 96.7% and 88.9%, respectively, and the difference was statistically significant (P <.001, log-rank test). With the use of a consolidation/tumor ratio 0.25 or less in cT1a, the 5-year overall survivals of radiologic noninvasive (35 patients, 12.1%) and invasive (254 patients, 87.9%) adenocarcinomas were 97.1% and 92.4%, respectively, and the difference was not statistically significant (P =.259). Conclusions: The radiologic criteria of a consolidation/tumor ratio 0.25 or less in cT1a (≤2.0 cm) and 0.50 in cT1a-b (≤3.0 cm) were both able to define a homogeneous group of patients with an excellent prognosis before surgery.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume146
Issue number1
DOIs
Publication statusPublished - 2013 Jul
Externally publishedYes

Fingerprint

Medical Oncology
Japan
Survival
Adenocarcinoma
Neoplasms
Adenocarcinoma of lung
Lymph Node Excision
Tomography
Pathology
Recurrence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Radiographically determined noninvasive adenocarcinoma of the lung : Survival outcomes of Japan Clinical Oncology Group 0201. / Asamura, Hisao; Hishida, Tomoyuki; Suzuki, Kenji; Koike, Teruaki; Nakamura, Kenichi; Kusumoto, Masahiko; Nagai, Kanji; Tada, Hirohito; Mitsudomi, Tetsuya; Tsuboi, Masahiro; Shibata, Taro; Fukuda, Haruhiko.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 146, No. 1, 07.2013, p. 24-30.

Research output: Contribution to journalArticle

Asamura, H, Hishida, T, Suzuki, K, Koike, T, Nakamura, K, Kusumoto, M, Nagai, K, Tada, H, Mitsudomi, T, Tsuboi, M, Shibata, T & Fukuda, H 2013, 'Radiographically determined noninvasive adenocarcinoma of the lung: Survival outcomes of Japan Clinical Oncology Group 0201', Journal of Thoracic and Cardiovascular Surgery, vol. 146, no. 1, pp. 24-30. https://doi.org/10.1016/j.jtcvs.2012.12.047
Asamura, Hisao ; Hishida, Tomoyuki ; Suzuki, Kenji ; Koike, Teruaki ; Nakamura, Kenichi ; Kusumoto, Masahiko ; Nagai, Kanji ; Tada, Hirohito ; Mitsudomi, Tetsuya ; Tsuboi, Masahiro ; Shibata, Taro ; Fukuda, Haruhiko. / Radiographically determined noninvasive adenocarcinoma of the lung : Survival outcomes of Japan Clinical Oncology Group 0201. In: Journal of Thoracic and Cardiovascular Surgery. 2013 ; Vol. 146, No. 1. pp. 24-30.
@article{596aed0a00c1406db301992c75af56ea,
title = "Radiographically determined noninvasive adenocarcinoma of the lung: Survival outcomes of Japan Clinical Oncology Group 0201",
abstract = "Objective: The study objective was to evaluate the long-term survival of patients with radiographically determined noninvasive lung adenocarcinomas. Methods: A prospective, multi-institutional study on image diagnosis to define early (noninvasive) adenocarcinomas of the lung (Japan Clinical Oncology Group 0201) has shown that a consolidation/tumor ratio on thin-section computed tomography 0.25 or less in cT1a (≤2.0 cm) could be used as a better radiologic criterion for a noninvasive pathology than a consolidation/tumor ratio 0.50 or less in cT1a-b (≤3.0 cm). From the prognostic viewpoints, these criteria were evaluated for 545 patients with adenocarcinoma who underwent lobectomy and lymph node dissection. Results: The subjects consisted of 233 men and 312 women with a median age of 62 years. The median follow-up period among overall patients was 7.1 years (range, 0-8.5 years). The overall and relapse-free 5-year survivals of the overall patients were 90.6{\%} and 84.7{\%}, respectively. When a consolidation/tumor ratio 0.5 or less in cT1a-b was used as a cutoff, the 5-year overall survivals of radiologic noninvasive (121 patients, 22.2{\%}) and invasive (424 patients, 77.8{\%}) adenocarcinomas were 96.7{\%} and 88.9{\%}, respectively, and the difference was statistically significant (P <.001, log-rank test). With the use of a consolidation/tumor ratio 0.25 or less in cT1a, the 5-year overall survivals of radiologic noninvasive (35 patients, 12.1{\%}) and invasive (254 patients, 87.9{\%}) adenocarcinomas were 97.1{\%} and 92.4{\%}, respectively, and the difference was not statistically significant (P =.259). Conclusions: The radiologic criteria of a consolidation/tumor ratio 0.25 or less in cT1a (≤2.0 cm) and 0.50 in cT1a-b (≤3.0 cm) were both able to define a homogeneous group of patients with an excellent prognosis before surgery.",
author = "Hisao Asamura and Tomoyuki Hishida and Kenji Suzuki and Teruaki Koike and Kenichi Nakamura and Masahiko Kusumoto and Kanji Nagai and Hirohito Tada and Tetsuya Mitsudomi and Masahiro Tsuboi and Taro Shibata and Haruhiko Fukuda",
year = "2013",
month = "7",
doi = "10.1016/j.jtcvs.2012.12.047",
language = "English",
volume = "146",
pages = "24--30",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Radiographically determined noninvasive adenocarcinoma of the lung

T2 - Survival outcomes of Japan Clinical Oncology Group 0201

AU - Asamura, Hisao

AU - Hishida, Tomoyuki

AU - Suzuki, Kenji

AU - Koike, Teruaki

AU - Nakamura, Kenichi

AU - Kusumoto, Masahiko

AU - Nagai, Kanji

AU - Tada, Hirohito

AU - Mitsudomi, Tetsuya

AU - Tsuboi, Masahiro

AU - Shibata, Taro

AU - Fukuda, Haruhiko

PY - 2013/7

Y1 - 2013/7

N2 - Objective: The study objective was to evaluate the long-term survival of patients with radiographically determined noninvasive lung adenocarcinomas. Methods: A prospective, multi-institutional study on image diagnosis to define early (noninvasive) adenocarcinomas of the lung (Japan Clinical Oncology Group 0201) has shown that a consolidation/tumor ratio on thin-section computed tomography 0.25 or less in cT1a (≤2.0 cm) could be used as a better radiologic criterion for a noninvasive pathology than a consolidation/tumor ratio 0.50 or less in cT1a-b (≤3.0 cm). From the prognostic viewpoints, these criteria were evaluated for 545 patients with adenocarcinoma who underwent lobectomy and lymph node dissection. Results: The subjects consisted of 233 men and 312 women with a median age of 62 years. The median follow-up period among overall patients was 7.1 years (range, 0-8.5 years). The overall and relapse-free 5-year survivals of the overall patients were 90.6% and 84.7%, respectively. When a consolidation/tumor ratio 0.5 or less in cT1a-b was used as a cutoff, the 5-year overall survivals of radiologic noninvasive (121 patients, 22.2%) and invasive (424 patients, 77.8%) adenocarcinomas were 96.7% and 88.9%, respectively, and the difference was statistically significant (P <.001, log-rank test). With the use of a consolidation/tumor ratio 0.25 or less in cT1a, the 5-year overall survivals of radiologic noninvasive (35 patients, 12.1%) and invasive (254 patients, 87.9%) adenocarcinomas were 97.1% and 92.4%, respectively, and the difference was not statistically significant (P =.259). Conclusions: The radiologic criteria of a consolidation/tumor ratio 0.25 or less in cT1a (≤2.0 cm) and 0.50 in cT1a-b (≤3.0 cm) were both able to define a homogeneous group of patients with an excellent prognosis before surgery.

AB - Objective: The study objective was to evaluate the long-term survival of patients with radiographically determined noninvasive lung adenocarcinomas. Methods: A prospective, multi-institutional study on image diagnosis to define early (noninvasive) adenocarcinomas of the lung (Japan Clinical Oncology Group 0201) has shown that a consolidation/tumor ratio on thin-section computed tomography 0.25 or less in cT1a (≤2.0 cm) could be used as a better radiologic criterion for a noninvasive pathology than a consolidation/tumor ratio 0.50 or less in cT1a-b (≤3.0 cm). From the prognostic viewpoints, these criteria were evaluated for 545 patients with adenocarcinoma who underwent lobectomy and lymph node dissection. Results: The subjects consisted of 233 men and 312 women with a median age of 62 years. The median follow-up period among overall patients was 7.1 years (range, 0-8.5 years). The overall and relapse-free 5-year survivals of the overall patients were 90.6% and 84.7%, respectively. When a consolidation/tumor ratio 0.5 or less in cT1a-b was used as a cutoff, the 5-year overall survivals of radiologic noninvasive (121 patients, 22.2%) and invasive (424 patients, 77.8%) adenocarcinomas were 96.7% and 88.9%, respectively, and the difference was statistically significant (P <.001, log-rank test). With the use of a consolidation/tumor ratio 0.25 or less in cT1a, the 5-year overall survivals of radiologic noninvasive (35 patients, 12.1%) and invasive (254 patients, 87.9%) adenocarcinomas were 97.1% and 92.4%, respectively, and the difference was not statistically significant (P =.259). Conclusions: The radiologic criteria of a consolidation/tumor ratio 0.25 or less in cT1a (≤2.0 cm) and 0.50 in cT1a-b (≤3.0 cm) were both able to define a homogeneous group of patients with an excellent prognosis before surgery.

UR - http://www.scopus.com/inward/record.url?scp=84879162188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879162188&partnerID=8YFLogxK

U2 - 10.1016/j.jtcvs.2012.12.047

DO - 10.1016/j.jtcvs.2012.12.047

M3 - Article

C2 - 23398645

AN - SCOPUS:84879162188

VL - 146

SP - 24

EP - 30

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 1

ER -