Radiopaque and biodegradable beads fabricated with Lipiodol and polycaprolactone for transarterial chemoembolization

Yutaka Okamoto, Kenta Bito, Terumitsu Hasebe, Tomohiro Matsumoto, Atsushi Hotta

Research output: Contribution to journalArticle

Abstract

Embolic beads for transarterial chemoembolization (TACE) should possess radiopacity and biodegradability at the same time, to be visualized in a body under fluoroscopy and CT scanning to avoid complicating disease. In this study, we fabricated radiopaque and biodegradable beads composed of Lipiodol (LPD) (ethiodized oil) and polycaprolactone (PCL), a biocompatible and biodegradable polymer. LPD/PCL beads were first fabricated with a home-made microfluidic device. By changing the flow-rate ratio in the microfluidic device, the mean diameter of LPD/PCL beads could be well controlled. The radiopacity was evaluated by the fluoroscopic imaging and the CT number measurements. Furthermore, the biodegradability was evaluated by collecting the weight loss data of LPD/PCL immersed in lipase/PBS solution and PBS. The results showed that LPD/PCL beads obtained in this study had sufficient radiopacity and biodegradability, which would be an alternative embolic agent for TACE.

Original languageEnglish
Pages (from-to)1187-1192
Number of pages6
JournalMRS Advances
Volume4
Issue number20
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Ethiodized Oil
Polycaprolactone
beads
biodegradability
Biodegradability
microfluidic devices
Microfluidics
fluoroscopy
Biodegradable polymers
Lipases
Lipase
flow velocity
oils
Flow rate
polycaprolactone
Scanning
Imaging techniques
scanning
polymers

Keywords

  • biomaterial
  • blend
  • microscale
  • polymer
  • x-ray fluorescence

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Radiopaque and biodegradable beads fabricated with Lipiodol and polycaprolactone for transarterial chemoembolization. / Okamoto, Yutaka; Bito, Kenta; Hasebe, Terumitsu; Matsumoto, Tomohiro; Hotta, Atsushi.

In: MRS Advances, Vol. 4, No. 20, 01.01.2019, p. 1187-1192.

Research output: Contribution to journalArticle

Okamoto, Yutaka ; Bito, Kenta ; Hasebe, Terumitsu ; Matsumoto, Tomohiro ; Hotta, Atsushi. / Radiopaque and biodegradable beads fabricated with Lipiodol and polycaprolactone for transarterial chemoembolization. In: MRS Advances. 2019 ; Vol. 4, No. 20. pp. 1187-1192.
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