Radiopaque hydrogel microfiber for arterial embolization

Naoki Takakura, Hiroki Ohta, Teppei Komatsu, Yuta Kurashina, Hirotaka J. Okano, Hiroaki Onoe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper proposes a radiopaque hydrogel microfiber for arterial embolization. The microfiber is made of barium alginate hydrogel containing zirconia (Radiopaque), and fabricated in a dual coaxial laminar flow microfluidic device. We confirmed that X-ray imaging was possible by encapsulating zirconia particles in hydrogel microfibers. Moreover the microfiber was successfully delivered into the target arteries of rats using a catheter to block blood flow for a long time. We believe that this microfiber would enable arterial embolization of cancerous tissues in various organs.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages320-321
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 2020 Oct 42020 Oct 9

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period20/10/420/10/9

Keywords

  • Barium alginate hydrogel
  • Cancer treatment
  • Catheter
  • Microfiber
  • X-ray

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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