Radiotherapy for hepatocellular carcinoma: Clinicopathological study of seven autopsy cases

K. Aoki, N. Okazaki, S. Okada, H. Nose, M. Yoshimori, Y. Akine, S. Egawa, M. Sakamoto, S. Hirohashi

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Abstract

The clinical value of radiotherapy for hepatocellular carcinoma (total tumor dose: 50- 70 Gy) was evaluated in seven autopsied patients with nine tumors. A partial response as defined by the WHO criteria for chemotherapy was observed in three tumors (33%). Progressive and marked shrinkage of the noncancerous liver tissue within the irradiated field was also observed in all cases. Histological examination revealed viable cancer cells in all cases. These results indicate that local radiotherapy applying 50-70 Gy achieved some clinical benefit, but was not capable of curing hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalHepato-gastroenterology
Volume41
Issue number5
Publication statusPublished - 1994 Jan 1

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Keywords

  • Hepatocellular carcinoma
  • Pathological analysis
  • Radiotherapy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Aoki, K., Okazaki, N., Okada, S., Nose, H., Yoshimori, M., Akine, Y., Egawa, S., Sakamoto, M., & Hirohashi, S. (1994). Radiotherapy for hepatocellular carcinoma: Clinicopathological study of seven autopsy cases. Hepato-gastroenterology, 41(5), 427-431.