Random-walk mechanism in the genetic recombination

Youhei Fujitani, Junji Kawai, Ichizo Kobayashi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We have explained some experimental data of the homologous recombination and the genetic interference in terms of one-dimensional random walk over discrete sites. We first review our previous results. Next, we modify our random-walk model for the homologous recombination into a continuous-site model, and discuss a possible explanation for the previous experimental data obtained by means of the plasmid having one-side homology. Finally, we show that a reaction between an intermediate and a product is indispensable in explaining the genetic interference in terms of our reaction-diffusion model.

Original languageEnglish
Title of host publicationAdvances in Computational Biology
EditorsHamid Arabnia
Pages275-282
Number of pages8
DOIs
Publication statusPublished - 2010 Dec 1

Publication series

NameAdvances in Experimental Medicine and Biology
Volume680
ISSN (Print)0065-2598

Keywords

  • Genetic interference
  • Homologous recombination
  • Homology
  • Plasmid
  • Random walk model
  • Reaction-diffusion model

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Fujitani, Y., Kawai, J., & Kobayashi, I. (2010). Random-walk mechanism in the genetic recombination. In H. Arabnia (Ed.), Advances in Computational Biology (pp. 275-282). (Advances in Experimental Medicine and Biology; Vol. 680). https://doi.org/10.1007/978-1-4419-5913-3_31