Random-walk model of homologous recombination

Youhei Fujitani, Ichizo Kobayashi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Interaction between two homologous (i.e., identical or nearly identical) DNA sequences leads to their homologous recombination in the cell. We present the following stochastic model to explain the dependence of the frequency of homologous recombination on the length of the homologous region. The branch point connecting the two DNAs in a reaction intermediate follows the random-walk process along the homology (N base-pairs). If the branch point reaches either of the homology ends, it bounds back to the homologous region at a probability of γ (reflection coefficient) and is destroyed at a probability of 1-γ. When γ is small, the frequency of homologous recombination is found to be proportional to N3 for smaller N and a linear function of N for larger N. The exponent of the nonlinear dependence for smaller N decreases from three as γ increases. When γ=1, only the linear dependence is left. These theoretical results can explain many experimental data in various systems. (c) 1995 The American Physical Society

Original languageEnglish
Pages (from-to)6607-6622
Number of pages16
JournalPhysical Review E
Volume52
Issue number6
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

random walk
Recombination
Random walk
Branch Point
homology
Homology
deoxyribonucleic acid
Linear dependence
reaction intermediates
Reflection Coefficient
DNA Sequence
Linear Function
Stochastic Model
Directly proportional
Exponent
Experimental Data
exponents
Model
reflectance
Decrease

ASJC Scopus subject areas

  • Mathematical Physics
  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics

Cite this

Random-walk model of homologous recombination. / Fujitani, Youhei; Kobayashi, Ichizo.

In: Physical Review E, Vol. 52, No. 6, 1995, p. 6607-6622.

Research output: Contribution to journalArticle

Fujitani, Youhei ; Kobayashi, Ichizo. / Random-walk model of homologous recombination. In: Physical Review E. 1995 ; Vol. 52, No. 6. pp. 6607-6622.
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