Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer

H. Hasegawa, Y. Kabeshima, M. Watanabe, S. Yamamoto, M. Kitajima

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Background: After confirming a favorable outcome of laparoscopic surgery for early colorectal cancer, we conducted a randomized controlled trial to compare short-term outcomes of laparoscopic and open colectomy for advanced colorectal cancer. Methods: Fifty-nine patients with T2 or T3 colorectal cancer were randomized to undergo laparoscopic (n = 29) or open (n = 30) colectomy. Median follow-up was 20 months (range, 6-34 months). Results: Operative time was longer (p < 0.0001) and blood loss (p = 0.0034) and postoperative analgesic requirement were less in the laparoscopic group than in the open group. An earlier return of bowel motility and earlier discharge from the hospital (p = 0.0164) were observed after laparoscopic surgery. Serum C-reactive protein levels on postoperative days 1 (p < 0.0001) and 4 (p = 0.0039) were lower in the laparoscopic group than in the open group. Postoperative complications did not differ between the two groups. Conclusion: Laparoscopic surgery for advanced colorectal cancer is feasible, with favorable short-term outcome.

Original languageEnglish
Pages (from-to)636-640
Number of pages5
JournalSurgical Endoscopy and Other Interventional Techniques
Volume17
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1

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Colectomy
Colorectal Neoplasms
Randomized Controlled Trials
Laparoscopy
Operative Time
C-Reactive Protein
Analgesics
Blood Proteins

Keywords

  • Colorectal cancer
  • Laparoscopic surgery
  • Randomized controlled trial
  • Short-term outcome

ASJC Scopus subject areas

  • Surgery

Cite this

Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer. / Hasegawa, H.; Kabeshima, Y.; Watanabe, M.; Yamamoto, S.; Kitajima, M.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 17, No. 4, 01.04.2003, p. 636-640.

Research output: Contribution to journalArticle

Hasegawa, H. ; Kabeshima, Y. ; Watanabe, M. ; Yamamoto, S. ; Kitajima, M. / Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer. In: Surgical Endoscopy and Other Interventional Techniques. 2003 ; Vol. 17, No. 4. pp. 636-640.
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