Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure

A. Kawamura, T. Yoshikawa, T. Takahashi, T. Hayashi, E. Takahashi, T. Anzai, T. Sato, S. Ogawa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Increased neurohormone and cytokine concentrations are associated with adverse outcome in patients with congestive heart failure, so minimizing these increases may improve outcome, even in the acute phase of decompensated heart failure. The present study was designed to test the hypothesis that phosphodiesterase inhibitors, but not catecholamines, could favorably affect neurohormone and cytokine profiles in patients with acutely decompensated heart failure. Twenty-nine patients underwent monitoring using a Swan-Ganz catheter and were randomly allocated to receive phosphodiesterase inhibitors (PDEI group, n=19) or catecholamines (CA group, n=10). Pulmonary capillary wedge pressure decreased significantly in both groups and cardiac output showed a slight, but not statistically significant increase, in both groups. There was a significant decrease in plasma brain natriuretic peptide concentration in the PDEI group, but not in the CA group, whereas plasma interleukin-6 concentration increased in the CA group, but not in the PDEI group. Phosphodiesterase inhibitors favorably affect neurohormone and cytokine concentrations in patients with acutely decompensated heart failure.

Original languageEnglish
Pages (from-to)858-862
Number of pages5
JournalJapanese Circulation Journal
Volume65
Issue number10
DOIs
Publication statusPublished - 2001

Fingerprint

Phosphodiesterase Inhibitors
Catecholamines
Heart Failure
Neurotransmitter Agents
Cytokines
Pulmonary Wedge Pressure
Brain Natriuretic Peptide
Physiologic Monitoring
Cardiac Output
Interleukin-6
Catheters

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Kawamura, A., Yoshikawa, T., Takahashi, T., Hayashi, T., Takahashi, E., Anzai, T., ... Ogawa, S. (2001). Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure. Japanese Circulation Journal, 65(10), 858-862. https://doi.org/10.1253/jcj.65.858

Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure. / Kawamura, A.; Yoshikawa, T.; Takahashi, T.; Hayashi, T.; Takahashi, E.; Anzai, T.; Sato, T.; Ogawa, S.

In: Japanese Circulation Journal, Vol. 65, No. 10, 2001, p. 858-862.

Research output: Contribution to journalArticle

Kawamura, A, Yoshikawa, T, Takahashi, T, Hayashi, T, Takahashi, E, Anzai, T, Sato, T & Ogawa, S 2001, 'Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure', Japanese Circulation Journal, vol. 65, no. 10, pp. 858-862. https://doi.org/10.1253/jcj.65.858
Kawamura, A. ; Yoshikawa, T. ; Takahashi, T. ; Hayashi, T. ; Takahashi, E. ; Anzai, T. ; Sato, T. ; Ogawa, S. / Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure. In: Japanese Circulation Journal. 2001 ; Vol. 65, No. 10. pp. 858-862.
@article{28bbee94b5a141b08fc234c84b4070c3,
title = "Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure",
abstract = "Increased neurohormone and cytokine concentrations are associated with adverse outcome in patients with congestive heart failure, so minimizing these increases may improve outcome, even in the acute phase of decompensated heart failure. The present study was designed to test the hypothesis that phosphodiesterase inhibitors, but not catecholamines, could favorably affect neurohormone and cytokine profiles in patients with acutely decompensated heart failure. Twenty-nine patients underwent monitoring using a Swan-Ganz catheter and were randomly allocated to receive phosphodiesterase inhibitors (PDEI group, n=19) or catecholamines (CA group, n=10). Pulmonary capillary wedge pressure decreased significantly in both groups and cardiac output showed a slight, but not statistically significant increase, in both groups. There was a significant decrease in plasma brain natriuretic peptide concentration in the PDEI group, but not in the CA group, whereas plasma interleukin-6 concentration increased in the CA group, but not in the PDEI group. Phosphodiesterase inhibitors favorably affect neurohormone and cytokine concentrations in patients with acutely decompensated heart failure.",
author = "A. Kawamura and T. Yoshikawa and T. Takahashi and T. Hayashi and E. Takahashi and T. Anzai and T. Sato and S. Ogawa",
year = "2001",
doi = "10.1253/jcj.65.858",
language = "English",
volume = "65",
pages = "858--862",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "10",

}

TY - JOUR

T1 - Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure

AU - Kawamura, A.

AU - Yoshikawa, T.

AU - Takahashi, T.

AU - Hayashi, T.

AU - Takahashi, E.

AU - Anzai, T.

AU - Sato, T.

AU - Ogawa, S.

PY - 2001

Y1 - 2001

N2 - Increased neurohormone and cytokine concentrations are associated with adverse outcome in patients with congestive heart failure, so minimizing these increases may improve outcome, even in the acute phase of decompensated heart failure. The present study was designed to test the hypothesis that phosphodiesterase inhibitors, but not catecholamines, could favorably affect neurohormone and cytokine profiles in patients with acutely decompensated heart failure. Twenty-nine patients underwent monitoring using a Swan-Ganz catheter and were randomly allocated to receive phosphodiesterase inhibitors (PDEI group, n=19) or catecholamines (CA group, n=10). Pulmonary capillary wedge pressure decreased significantly in both groups and cardiac output showed a slight, but not statistically significant increase, in both groups. There was a significant decrease in plasma brain natriuretic peptide concentration in the PDEI group, but not in the CA group, whereas plasma interleukin-6 concentration increased in the CA group, but not in the PDEI group. Phosphodiesterase inhibitors favorably affect neurohormone and cytokine concentrations in patients with acutely decompensated heart failure.

AB - Increased neurohormone and cytokine concentrations are associated with adverse outcome in patients with congestive heart failure, so minimizing these increases may improve outcome, even in the acute phase of decompensated heart failure. The present study was designed to test the hypothesis that phosphodiesterase inhibitors, but not catecholamines, could favorably affect neurohormone and cytokine profiles in patients with acutely decompensated heart failure. Twenty-nine patients underwent monitoring using a Swan-Ganz catheter and were randomly allocated to receive phosphodiesterase inhibitors (PDEI group, n=19) or catecholamines (CA group, n=10). Pulmonary capillary wedge pressure decreased significantly in both groups and cardiac output showed a slight, but not statistically significant increase, in both groups. There was a significant decrease in plasma brain natriuretic peptide concentration in the PDEI group, but not in the CA group, whereas plasma interleukin-6 concentration increased in the CA group, but not in the PDEI group. Phosphodiesterase inhibitors favorably affect neurohormone and cytokine concentrations in patients with acutely decompensated heart failure.

UR - http://www.scopus.com/inward/record.url?scp=0034765666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034765666&partnerID=8YFLogxK

U2 - 10.1253/jcj.65.858

DO - 10.1253/jcj.65.858

M3 - Article

C2 - 11665788

AN - SCOPUS:0034765666

VL - 65

SP - 858

EP - 862

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 10

ER -