Abstract
Increased neurohormone and cytokine concentrations are associated with adverse outcome in patients with congestive heart failure, so minimizing these increases may improve outcome, even in the acute phase of decompensated heart failure. The present study was designed to test the hypothesis that phosphodiesterase inhibitors, but not catecholamines, could favorably affect neurohormone and cytokine profiles in patients with acutely decompensated heart failure. Twenty-nine patients underwent monitoring using a Swan-Ganz catheter and were randomly allocated to receive phosphodiesterase inhibitors (PDEI group, n=19) or catecholamines (CA group, n=10). Pulmonary capillary wedge pressure decreased significantly in both groups and cardiac output showed a slight, but not statistically significant increase, in both groups. There was a significant decrease in plasma brain natriuretic peptide concentration in the PDEI group, but not in the CA group, whereas plasma interleukin-6 concentration increased in the CA group, but not in the PDEI group. Phosphodiesterase inhibitors favorably affect neurohormone and cytokine concentrations in patients with acutely decompensated heart failure.
| Original language | English |
|---|---|
| Pages (from-to) | 858-862 |
| Number of pages | 5 |
| Journal | Japanese Circulation Journal |
| Volume | 65 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology
Cite this
Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure. / Kawamura, A.; Yoshikawa, T.; Takahashi, T.; Hayashi, T.; Takahashi, E.; Anzai, T.; Sato, T.; Ogawa, S.
In: Japanese Circulation Journal, Vol. 65, No. 10, 2001, p. 858-862.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure
AU - Kawamura, A.
AU - Yoshikawa, T.
AU - Takahashi, T.
AU - Hayashi, T.
AU - Takahashi, E.
AU - Anzai, T.
AU - Sato, T.
AU - Ogawa, S.
PY - 2001
Y1 - 2001
N2 - Increased neurohormone and cytokine concentrations are associated with adverse outcome in patients with congestive heart failure, so minimizing these increases may improve outcome, even in the acute phase of decompensated heart failure. The present study was designed to test the hypothesis that phosphodiesterase inhibitors, but not catecholamines, could favorably affect neurohormone and cytokine profiles in patients with acutely decompensated heart failure. Twenty-nine patients underwent monitoring using a Swan-Ganz catheter and were randomly allocated to receive phosphodiesterase inhibitors (PDEI group, n=19) or catecholamines (CA group, n=10). Pulmonary capillary wedge pressure decreased significantly in both groups and cardiac output showed a slight, but not statistically significant increase, in both groups. There was a significant decrease in plasma brain natriuretic peptide concentration in the PDEI group, but not in the CA group, whereas plasma interleukin-6 concentration increased in the CA group, but not in the PDEI group. Phosphodiesterase inhibitors favorably affect neurohormone and cytokine concentrations in patients with acutely decompensated heart failure.
AB - Increased neurohormone and cytokine concentrations are associated with adverse outcome in patients with congestive heart failure, so minimizing these increases may improve outcome, even in the acute phase of decompensated heart failure. The present study was designed to test the hypothesis that phosphodiesterase inhibitors, but not catecholamines, could favorably affect neurohormone and cytokine profiles in patients with acutely decompensated heart failure. Twenty-nine patients underwent monitoring using a Swan-Ganz catheter and were randomly allocated to receive phosphodiesterase inhibitors (PDEI group, n=19) or catecholamines (CA group, n=10). Pulmonary capillary wedge pressure decreased significantly in both groups and cardiac output showed a slight, but not statistically significant increase, in both groups. There was a significant decrease in plasma brain natriuretic peptide concentration in the PDEI group, but not in the CA group, whereas plasma interleukin-6 concentration increased in the CA group, but not in the PDEI group. Phosphodiesterase inhibitors favorably affect neurohormone and cytokine concentrations in patients with acutely decompensated heart failure.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034765666&partnerID=8YFLogxK
U2 - 10.1253/jcj.65.858
DO - 10.1253/jcj.65.858
M3 - Article
C2 - 11665788
AN - SCOPUS:0034765666
VL - 65
SP - 858
EP - 862
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 10
ER -