Abstract
Diffusion sensors for nano-sized materials dispersed in a solution are promising tools for investigating intermolecular interactions, which is an important task in a wide range of industrial and biomedical fields, such as the development of therapeutic products and diagnostic tools. For the development of the sensor applicable to point-of-care testing, an optofluidic sensor was proposed. The proposed sensor realizes a simple measurement in a short time using microscale manipulation by interferometrically-induced dielectrophoresis and optical detection. In this paper, the applicability of the proposed sensor to distinguish nanoscale differences in size was confirmed by measurements on a solution containing size-certified plain nano-beads (51 nm, 100 nm, 203 nm, 216 nm and 240 nm) with evaluating the uncertainties of the proposed sensor. Furthermore, measurements using 200-nm beads coated with functional groups (NH2 and biotin) and proteins (streptavidin and bovine serum albumin) demonstrated the applicability to the investigation of intermolecular interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 73-79 |
| Number of pages | 7 |
| Journal | International Journal of Heat and Mass Transfer |
| Volume | 133 |
| DOIs | |
| Publication status | Published - 2019 Apr 1 |
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Keywords
- Diffusion coefficient
- Intermolecular interaction
- Label-free sensing
- Laser-induced dielectrophoresis
- Optofluidic sensor
- Rapid measurement
ASJC Scopus subject areas
- Condensed Matter Physics
- Mechanical Engineering
- Fluid Flow and Transfer Processes
Cite this
Rapid and label-free sensing of intermolecular interactions using compact optical diffusion sensor. / Kamata, Makoto; Takaba, Yoshiaki; Taguchi, Yoshihiro; Nagasaka, Yuji.
In: International Journal of Heat and Mass Transfer, Vol. 133, 01.04.2019, p. 73-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rapid and label-free sensing of intermolecular interactions using compact optical diffusion sensor
AU - Kamata, Makoto
AU - Takaba, Yoshiaki
AU - Taguchi, Yoshihiro
AU - Nagasaka, Yuji
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Diffusion sensors for nano-sized materials dispersed in a solution are promising tools for investigating intermolecular interactions, which is an important task in a wide range of industrial and biomedical fields, such as the development of therapeutic products and diagnostic tools. For the development of the sensor applicable to point-of-care testing, an optofluidic sensor was proposed. The proposed sensor realizes a simple measurement in a short time using microscale manipulation by interferometrically-induced dielectrophoresis and optical detection. In this paper, the applicability of the proposed sensor to distinguish nanoscale differences in size was confirmed by measurements on a solution containing size-certified plain nano-beads (51 nm, 100 nm, 203 nm, 216 nm and 240 nm) with evaluating the uncertainties of the proposed sensor. Furthermore, measurements using 200-nm beads coated with functional groups (NH2 and biotin) and proteins (streptavidin and bovine serum albumin) demonstrated the applicability to the investigation of intermolecular interactions.
AB - Diffusion sensors for nano-sized materials dispersed in a solution are promising tools for investigating intermolecular interactions, which is an important task in a wide range of industrial and biomedical fields, such as the development of therapeutic products and diagnostic tools. For the development of the sensor applicable to point-of-care testing, an optofluidic sensor was proposed. The proposed sensor realizes a simple measurement in a short time using microscale manipulation by interferometrically-induced dielectrophoresis and optical detection. In this paper, the applicability of the proposed sensor to distinguish nanoscale differences in size was confirmed by measurements on a solution containing size-certified plain nano-beads (51 nm, 100 nm, 203 nm, 216 nm and 240 nm) with evaluating the uncertainties of the proposed sensor. Furthermore, measurements using 200-nm beads coated with functional groups (NH2 and biotin) and proteins (streptavidin and bovine serum albumin) demonstrated the applicability to the investigation of intermolecular interactions.
KW - Diffusion coefficient
KW - Intermolecular interaction
KW - Label-free sensing
KW - Laser-induced dielectrophoresis
KW - Optofluidic sensor
KW - Rapid measurement
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U2 - 10.1016/j.ijheatmasstransfer.2018.12.088
DO - 10.1016/j.ijheatmasstransfer.2018.12.088
M3 - Article
AN - SCOPUS:85058643698
VL - 133
SP - 73
EP - 79
JO - International Journal of Heat and Mass Transfer
JF - International Journal of Heat and Mass Transfer
SN - 0017-9310
ER -