Rapid Changes in Pial Arterial Diameter and Cerebral Blood Flow Caused by Ipsilateral Carotid Artery Occlusion in Rats

Yoko Morita, Yasuo Fukuuchi, Atsuo Koto, Norihiro Suzuki, Kazuo Isozumi, Jun Gotoh, Toshihiko Shimizu, Masaki Takao, Masahiro Aoyama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We investigated rapid changes in pial arterial diameter and in cerebral blood flow (CBF) caused by transient ipsilateral common carotid artery occlusion (CCA-O) in anesthetized rats in order to elucidate how the cerebral circulation reacts to acute stem artery occlusion. In separate groups of rats, pial arterial diameter was recorded through a closed cranial window and CBF was recorded by laser-Doppler flowmetry. CCA-O was performed for 5 minutes under normotension and normocapnia (control) and under graded hypotension, hypercapnia and hypocapnia. In the control condition, pial arterial diameter increased rapidly, triggered by CCA-O. It took 12 ± 3 s to reach the maximum of 204 ± 42% of the value before CCA-O, and 60 ± 24 s to become stable at 131 ± 11%. CBF decreased rapidly to 66 ± 11%, then increased reactively to 135 ± 9%, and again decreased to 91 ± 3%. The reactive increase in CBF caused by CCA-O decreased in parallel with the degree of hypotension, and also became barely detectable under hypercapnia. Our data suggest that active vascular dilation in the territory of the occluded artery is important for inducing collateral circulation.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalKeio Journal of Medicine
Volume46
Issue number3
Publication statusPublished - 1997 Sep

Fingerprint

Cerebrovascular Circulation
Carotid Arteries
Common Carotid Artery
Hypercapnia
Hypotension
Arteries
Hypocapnia
Collateral Circulation
Laser-Doppler Flowmetry
Blood Vessels
Dilatation

Keywords

  • Carotid occlusion
  • Cerebral blood flow
  • Collateral circulation
  • Pial artery
  • Reactive hyperemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Morita, Y., Fukuuchi, Y., Koto, A., Suzuki, N., Isozumi, K., Gotoh, J., ... Aoyama, M. (1997). Rapid Changes in Pial Arterial Diameter and Cerebral Blood Flow Caused by Ipsilateral Carotid Artery Occlusion in Rats. Keio Journal of Medicine, 46(3), 120-127.

Rapid Changes in Pial Arterial Diameter and Cerebral Blood Flow Caused by Ipsilateral Carotid Artery Occlusion in Rats. / Morita, Yoko; Fukuuchi, Yasuo; Koto, Atsuo; Suzuki, Norihiro; Isozumi, Kazuo; Gotoh, Jun; Shimizu, Toshihiko; Takao, Masaki; Aoyama, Masahiro.

In: Keio Journal of Medicine, Vol. 46, No. 3, 09.1997, p. 120-127.

Research output: Contribution to journalArticle

Morita, Y, Fukuuchi, Y, Koto, A, Suzuki, N, Isozumi, K, Gotoh, J, Shimizu, T, Takao, M & Aoyama, M 1997, 'Rapid Changes in Pial Arterial Diameter and Cerebral Blood Flow Caused by Ipsilateral Carotid Artery Occlusion in Rats', Keio Journal of Medicine, vol. 46, no. 3, pp. 120-127.
Morita, Yoko ; Fukuuchi, Yasuo ; Koto, Atsuo ; Suzuki, Norihiro ; Isozumi, Kazuo ; Gotoh, Jun ; Shimizu, Toshihiko ; Takao, Masaki ; Aoyama, Masahiro. / Rapid Changes in Pial Arterial Diameter and Cerebral Blood Flow Caused by Ipsilateral Carotid Artery Occlusion in Rats. In: Keio Journal of Medicine. 1997 ; Vol. 46, No. 3. pp. 120-127.
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