Abstract
Aim: To investigate the long term effects of cardiac events on renal function, a prospective study of patients with acute myocardial infarction was conducted. Methods: A total of 137 patients with acute myocardial infarction were followed for 1 year. The change of estimated glomerular filtration rate (eGFR) in cardiac patients was compared with that in background-matched controls, and the factors associated with eGFR changes were analyzed. Results: The eGFR decrease was much larger after myocardial infarction, from 73.7 ± 1.9 ml/ min/1.73 m2 (mean ± SEM) at baseline to 64.7 ± 1.7 at 1 year, (p <0.001), compared with that of controls (from 72.8 ± 1.2 to 72.1 ± 1.3, p = 0.305). Multiple regression analysis showed that eGFR change was associated negatively with age, baseline eGFR, proteinuria, and positively with the administration of angiotensin converting enzyme inhibitors or angiotensin II receptor blockers, but not the severity of cardiac damage and comorbidities. Longitudinal analysis 1 year before and 2 years after myocardial infarction showed that eGFR decrease was larger during baseline and 6 months after the event (-7.0 ± 1.0). Conclusions: Renal decline was rapid after myocardial infarction and was affected by clinical characteristics of patients. Careful follow-up of renal function is recommended to prevent the progression of renal and cardiac disease
| Original language | English |
|---|---|
| Pages (from-to) | 15-20 |
| Number of pages | 6 |
| Journal | Clinical Nephrology |
| Volume | 79 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
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Keywords
- Cardiac event
- Chronic kidney disease
- Glomerular filtration rate
- Myocardial infarction
- Renal failure
ASJC Scopus subject areas
- Nephrology
Cite this
Rapid decline in renal function after acute myocardial infarction. / Mashima, Yusuke; Konta, Tsuneo; Ichikawa, Kazunobu; Ikeda, Ami; Suzuki, Kazuko; Wanezaki, Masahiro; Nishiyama, Satoshi; Watanabe, Tetsu; Kubota, Isao.
In: Clinical Nephrology, Vol. 79, No. 1, 2013, p. 15-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rapid decline in renal function after acute myocardial infarction
AU - Mashima, Yusuke
AU - Konta, Tsuneo
AU - Ichikawa, Kazunobu
AU - Ikeda, Ami
AU - Suzuki, Kazuko
AU - Wanezaki, Masahiro
AU - Nishiyama, Satoshi
AU - Watanabe, Tetsu
AU - Kubota, Isao
PY - 2013
Y1 - 2013
N2 - Aim: To investigate the long term effects of cardiac events on renal function, a prospective study of patients with acute myocardial infarction was conducted. Methods: A total of 137 patients with acute myocardial infarction were followed for 1 year. The change of estimated glomerular filtration rate (eGFR) in cardiac patients was compared with that in background-matched controls, and the factors associated with eGFR changes were analyzed. Results: The eGFR decrease was much larger after myocardial infarction, from 73.7 ± 1.9 ml/ min/1.73 m2 (mean ± SEM) at baseline to 64.7 ± 1.7 at 1 year, (p <0.001), compared with that of controls (from 72.8 ± 1.2 to 72.1 ± 1.3, p = 0.305). Multiple regression analysis showed that eGFR change was associated negatively with age, baseline eGFR, proteinuria, and positively with the administration of angiotensin converting enzyme inhibitors or angiotensin II receptor blockers, but not the severity of cardiac damage and comorbidities. Longitudinal analysis 1 year before and 2 years after myocardial infarction showed that eGFR decrease was larger during baseline and 6 months after the event (-7.0 ± 1.0). Conclusions: Renal decline was rapid after myocardial infarction and was affected by clinical characteristics of patients. Careful follow-up of renal function is recommended to prevent the progression of renal and cardiac disease
AB - Aim: To investigate the long term effects of cardiac events on renal function, a prospective study of patients with acute myocardial infarction was conducted. Methods: A total of 137 patients with acute myocardial infarction were followed for 1 year. The change of estimated glomerular filtration rate (eGFR) in cardiac patients was compared with that in background-matched controls, and the factors associated with eGFR changes were analyzed. Results: The eGFR decrease was much larger after myocardial infarction, from 73.7 ± 1.9 ml/ min/1.73 m2 (mean ± SEM) at baseline to 64.7 ± 1.7 at 1 year, (p <0.001), compared with that of controls (from 72.8 ± 1.2 to 72.1 ± 1.3, p = 0.305). Multiple regression analysis showed that eGFR change was associated negatively with age, baseline eGFR, proteinuria, and positively with the administration of angiotensin converting enzyme inhibitors or angiotensin II receptor blockers, but not the severity of cardiac damage and comorbidities. Longitudinal analysis 1 year before and 2 years after myocardial infarction showed that eGFR decrease was larger during baseline and 6 months after the event (-7.0 ± 1.0). Conclusions: Renal decline was rapid after myocardial infarction and was affected by clinical characteristics of patients. Careful follow-up of renal function is recommended to prevent the progression of renal and cardiac disease
KW - Cardiac event
KW - Chronic kidney disease
KW - Glomerular filtration rate
KW - Myocardial infarction
KW - Renal failure
UR - http://www.scopus.com/inward/record.url?scp=84873707656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873707656&partnerID=8YFLogxK
U2 - 10.5414/CN107645
DO - 10.5414/CN107645
M3 - Article
C2 - 22909784
AN - SCOPUS:84873707656
VL - 79
SP - 15
EP - 20
JO - Clinical Nephrology
JF - Clinical Nephrology
SN - 0301-0430
IS - 1
ER -