Rapid decline in renal function after acute myocardial infarction

Yusuke Mashima, Tsuneo Konta, Kazunobu Ichikawa, Ami Ikeda, Kazuko Suzuki, Masahiro Wanezaki, Satoshi Nishiyama, Tetsu Watanabe, Isao Kubota

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Aim: To investigate the long term effects of cardiac events on renal function, a prospective study of patients with acute myocardial infarction was conducted. Methods: A total of 137 patients with acute myocardial infarction were followed for 1 year. The change of estimated glomerular filtration rate (eGFR) in cardiac patients was compared with that in background-matched controls, and the factors associated with eGFR changes were analyzed. Results: The eGFR decrease was much larger after myocardial infarction, from 73.7 ± 1.9 ml/ min/1.73 m2 (mean ± SEM) at baseline to 64.7 ± 1.7 at 1 year, (p <0.001), compared with that of controls (from 72.8 ± 1.2 to 72.1 ± 1.3, p = 0.305). Multiple regression analysis showed that eGFR change was associated negatively with age, baseline eGFR, proteinuria, and positively with the administration of angiotensin converting enzyme inhibitors or angiotensin II receptor blockers, but not the severity of cardiac damage and comorbidities. Longitudinal analysis 1 year before and 2 years after myocardial infarction showed that eGFR decrease was larger during baseline and 6 months after the event (-7.0 ± 1.0). Conclusions: Renal decline was rapid after myocardial infarction and was affected by clinical characteristics of patients. Careful follow-up of renal function is recommended to prevent the progression of renal and cardiac disease

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalClinical Nephrology
Volume79
Issue number1
DOIs
Publication statusPublished - 2013 Feb 19

Keywords

  • Cardiac event
  • Chronic kidney disease
  • Glomerular filtration rate
  • Myocardial infarction
  • Renal failure

ASJC Scopus subject areas

  • Nephrology

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