Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol

Takeshi Adachi, Shingo Hori, Koji Miyazaki, Eiichi Takahashi, Masahiro Nakagawa, Akira Udagawa, Nariyuki Hayashi, Naoki Aikawa, Satoshi Ogawa

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16 Citations (Scopus)

Abstract

Nipradilol, a β-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO2 group. In anesthetized dogs, the time course of the systemic vasodilatation and plasma nitrite (NO-2) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A fall in systemic vascular resistance was observed at 1 min, which was rapidly followed by a significant increase in the plasma NO-2 concentration. It is indicated that nipradilol exerts systemic vasodilatation via nitric oxide (NO) release in vivo.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalEuropean journal of pharmacology
Volume286
Issue number2
DOIs
Publication statusPublished - 1995 Nov 14

Keywords

  • Nipradilol
  • Nitric oxide (NO)
  • Nitrite
  • cGMP

ASJC Scopus subject areas

  • Pharmacology

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    Adachi, T., Hori, S., Miyazaki, K., Takahashi, E., Nakagawa, M., Udagawa, A., Hayashi, N., Aikawa, N., & Ogawa, S. (1995). Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol. European journal of pharmacology, 286(2), 201-204. https://doi.org/10.1016/0014-2999(95)00559-4