Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol

Takeshi Adachi, Shingo Hori, Koji Miyazaki, Eiichi Takahashi, Masahiro Nakagawa, Akira Udagawa, Nariyuki Hayashi, Naoki Aikawa, Satoshi Ogawa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Nipradilol, a β-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO2 group. In anesthetized dogs, the time course of the systemic vasodilatation and plasma nitrite (NO- 2) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A fall in systemic vascular resistance was observed at 1 min, which was rapidly followed by a significant increase in the plasma NO- 2 concentration. It is indicated that nipradilol exerts systemic vasodilatation via nitric oxide (NO) release in vivo.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalEuropean Journal of Pharmacology
Volume286
Issue number2
DOIs
Publication statusPublished - 1995 Nov 14

Fingerprint

Nitrites
Intravenous Administration
Nitric Oxide
Vasodilation
Vasodilator Agents
Vascular Resistance
Adrenergic Receptors
Dogs
nipradilol

Keywords

  • cGMP
  • Nipradilol
  • Nitric oxide (NO)
  • Nitrite

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Adachi, T., Hori, S., Miyazaki, K., Takahashi, E., Nakagawa, M., Udagawa, A., ... Ogawa, S. (1995). Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol. European Journal of Pharmacology, 286(2), 201-204. https://doi.org/10.1016/0014-2999(95)00559-4

Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol. / Adachi, Takeshi; Hori, Shingo; Miyazaki, Koji; Takahashi, Eiichi; Nakagawa, Masahiro; Udagawa, Akira; Hayashi, Nariyuki; Aikawa, Naoki; Ogawa, Satoshi.

In: European Journal of Pharmacology, Vol. 286, No. 2, 14.11.1995, p. 201-204.

Research output: Contribution to journalArticle

Adachi, T, Hori, S, Miyazaki, K, Takahashi, E, Nakagawa, M, Udagawa, A, Hayashi, N, Aikawa, N & Ogawa, S 1995, 'Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol', European Journal of Pharmacology, vol. 286, no. 2, pp. 201-204. https://doi.org/10.1016/0014-2999(95)00559-4
Adachi, Takeshi ; Hori, Shingo ; Miyazaki, Koji ; Takahashi, Eiichi ; Nakagawa, Masahiro ; Udagawa, Akira ; Hayashi, Nariyuki ; Aikawa, Naoki ; Ogawa, Satoshi. / Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol. In: European Journal of Pharmacology. 1995 ; Vol. 286, No. 2. pp. 201-204.
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