Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin

Claus Gruss, Detlef Zillikens, Takashi Hashimoto, Masayuki Amagai, Maximilian Kroiss, Thomas Vogt, Michael Landthaler, Wilhelm Stolz

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Diagnosing IgA pemphigus and distinguishing between its 2 subtypes, intraepidermal neutrophilic IgA dermatosis type and subcorneal pustular dermatosis type, is important because treatment of IgA pemphigus has to be different from treatment of other blistering autoimmune dermatoses. We present a patient with subcorneal pustular dermatosis type of IgA pemphigus who rapidly responded to systemic treatment with isotretinoin. Specific diagnosis was established by detecting IgA serum activity to desmocollin 1 by indirect immunofluorescence microscopy on unfixed COS7 cells transfected with desmocollin 1. No IgA or IgG serum reactivity was found to recombinant forms of desmogleins 1 and 3 by an antigen-specific enzyme-linked immunosorbent assay. The disease was not effectively controlled by conventional therapeutic regimens. Systemic treatment with isotretinoin 20 mg daily led to complete clearance of skin lesions within 3 weeks. Assaying IgA serum reactivity to desmocollin 1, desmoglein 1, and desmoglein 3 as a valuable method for establishing the diagnosis and differentiating the 2 subtypes of IgA pemphigus. Isotretinoin was an effective drug in the treatment of subcorneal pustular dermatosis type of IgA pemphigus in this patient.

Original languageEnglish
Pages (from-to)923-926
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume43
Issue number5 SPEC. SUPPL.
Publication statusPublished - 2000
Externally publishedYes

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Vesiculobullous Skin Diseases
Isotretinoin
Pemphigus
Immunoglobulin A
Desmocollins
Desmoglein 3
Desmoglein 1
Therapeutics
Skin Diseases
Serum
Indirect Fluorescent Antibody Technique
Fluorescence Microscopy
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Antigens

ASJC Scopus subject areas

  • Dermatology

Cite this

Gruss, C., Zillikens, D., Hashimoto, T., Amagai, M., Kroiss, M., Vogt, T., ... Stolz, W. (2000). Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin. Journal of the American Academy of Dermatology, 43(5 SPEC. SUPPL.), 923-926.

Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin. / Gruss, Claus; Zillikens, Detlef; Hashimoto, Takashi; Amagai, Masayuki; Kroiss, Maximilian; Vogt, Thomas; Landthaler, Michael; Stolz, Wilhelm.

In: Journal of the American Academy of Dermatology, Vol. 43, No. 5 SPEC. SUPPL., 2000, p. 923-926.

Research output: Contribution to journalArticle

Gruss, C, Zillikens, D, Hashimoto, T, Amagai, M, Kroiss, M, Vogt, T, Landthaler, M & Stolz, W 2000, 'Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin', Journal of the American Academy of Dermatology, vol. 43, no. 5 SPEC. SUPPL., pp. 923-926.
Gruss, Claus ; Zillikens, Detlef ; Hashimoto, Takashi ; Amagai, Masayuki ; Kroiss, Maximilian ; Vogt, Thomas ; Landthaler, Michael ; Stolz, Wilhelm. / Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin. In: Journal of the American Academy of Dermatology. 2000 ; Vol. 43, No. 5 SPEC. SUPPL. pp. 923-926.
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