Abstract
Early gastric cancer has an excellent outcome following surgical treatment. In particular, mucosal gastric cancer (m-cancer) very rarely results in metastatic dissemination and may be successfully treated by local surgical resection. We report a 64-year-old Japanese woman who presented with a recurrent cystic lesion on the left bulbar conjunctiva, with a biopsy specimen revealing metastatic signet-ring cell carcinoma. Gastrointestinal investigations revealed an early gastric cancer in the lesser curvature of the stomach. Biopsy specimen of the gastric lesion indicated poorly differentiated adenocarcinoma, which was identical to findings in the lesion in the bulbar conjunctiva. She underwent a distal gastrectomy and made an uneventful recovery. Histopathological analysis indicated a gastric signet-ring cell carcinoma that was limited to the mucosal layer, without evidence of lymphatic spread. Although the exact mechanism of metastatic dissemination to the bulbar conjunctiva is unclear, this case is very unusual, because ocular metastases almost invariably occur in the context of documented and established malignant disease. This is, to our knowledge, the first reported case of a patient with gastric mucosal cancer who presented with a conjunctival metastatic deposit and who subsequently received curative surgical treatment for both conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 102-106 |
| Number of pages | 5 |
| Journal | Gastric Cancer |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Distant metastasis
- Mucosal gastric cancer
ASJC Scopus subject areas
- Oncology
- Gastroenterology
- Cancer Research
Cite this
Rare case of early mucosal gastric cancer presenting with metastasis to the bulbar conjunctiva. / Tokuyama, Jo; Kubota, Tetsuro; Otani, Yoshihide; Egawa, Tomohisa; Wada, Norihito; Sugino, Yoshinori; Mashima, Yukihiro; Nakamura, Yu; Mukai, Makio; Ishii, Hiromasa; Kitajima, Masaki.
In: Gastric Cancer, Vol. 5, No. 2, 2002, p. 102-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rare case of early mucosal gastric cancer presenting with metastasis to the bulbar conjunctiva
AU - Tokuyama, Jo
AU - Kubota, Tetsuro
AU - Otani, Yoshihide
AU - Egawa, Tomohisa
AU - Wada, Norihito
AU - Sugino, Yoshinori
AU - Mashima, Yukihiro
AU - Nakamura, Yu
AU - Mukai, Makio
AU - Ishii, Hiromasa
AU - Kitajima, Masaki
PY - 2002
Y1 - 2002
N2 - Early gastric cancer has an excellent outcome following surgical treatment. In particular, mucosal gastric cancer (m-cancer) very rarely results in metastatic dissemination and may be successfully treated by local surgical resection. We report a 64-year-old Japanese woman who presented with a recurrent cystic lesion on the left bulbar conjunctiva, with a biopsy specimen revealing metastatic signet-ring cell carcinoma. Gastrointestinal investigations revealed an early gastric cancer in the lesser curvature of the stomach. Biopsy specimen of the gastric lesion indicated poorly differentiated adenocarcinoma, which was identical to findings in the lesion in the bulbar conjunctiva. She underwent a distal gastrectomy and made an uneventful recovery. Histopathological analysis indicated a gastric signet-ring cell carcinoma that was limited to the mucosal layer, without evidence of lymphatic spread. Although the exact mechanism of metastatic dissemination to the bulbar conjunctiva is unclear, this case is very unusual, because ocular metastases almost invariably occur in the context of documented and established malignant disease. This is, to our knowledge, the first reported case of a patient with gastric mucosal cancer who presented with a conjunctival metastatic deposit and who subsequently received curative surgical treatment for both conditions.
AB - Early gastric cancer has an excellent outcome following surgical treatment. In particular, mucosal gastric cancer (m-cancer) very rarely results in metastatic dissemination and may be successfully treated by local surgical resection. We report a 64-year-old Japanese woman who presented with a recurrent cystic lesion on the left bulbar conjunctiva, with a biopsy specimen revealing metastatic signet-ring cell carcinoma. Gastrointestinal investigations revealed an early gastric cancer in the lesser curvature of the stomach. Biopsy specimen of the gastric lesion indicated poorly differentiated adenocarcinoma, which was identical to findings in the lesion in the bulbar conjunctiva. She underwent a distal gastrectomy and made an uneventful recovery. Histopathological analysis indicated a gastric signet-ring cell carcinoma that was limited to the mucosal layer, without evidence of lymphatic spread. Although the exact mechanism of metastatic dissemination to the bulbar conjunctiva is unclear, this case is very unusual, because ocular metastases almost invariably occur in the context of documented and established malignant disease. This is, to our knowledge, the first reported case of a patient with gastric mucosal cancer who presented with a conjunctival metastatic deposit and who subsequently received curative surgical treatment for both conditions.
KW - Distant metastasis
KW - Mucosal gastric cancer
UR - http://www.scopus.com/inward/record.url?scp=0035986053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035986053&partnerID=8YFLogxK
U2 - 10.1007/s101200200017
DO - 10.1007/s101200200017
M3 - Article
C2 - 12111586
AN - SCOPUS:0035986053
VL - 5
SP - 102
EP - 106
JO - Gastric Cancer
JF - Gastric Cancer
SN - 1436-3291
IS - 2
ER -