Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents

Keisuke Ishida, Siro Simizu, Takayuki Teruya, Michal K. Wierzba, Hiroyuki Osada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A biological evaluation of the antiadhesive activity of novel heparan sulfate glycosaminoglycans mimetic compounds (KI-compounds) is described. In an adhesion assay, KI-111 [2-(4-fluoro-3-nitrobenzoyl)benzoic acetic anhydride] was found to exert potent inhibitory activities against the adhesion of human fibrosarcoma HT1080 cells and HeLa cells to fibronectin. Cell growth, migration, and invasion of HT1080 cells were also inhibited by KI-111 at almost equal concentrations.

Original languageEnglish
Pages (from-to)2505-2509
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number10
DOIs
Publication statusPublished - 2004 May 17

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Keywords

  • Antitumor
  • Drug design
  • Heparan sulfate mimetic

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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