Rationale and study design of the Japan environment and children's study (JECS)

Toshihiro Kawamoto, Hiroshi Nitta, Katsuyuki Murata, Eisaku Toda, Naoya Tsukamoto, Manabu Hasegawa, Zentaro Yamagata, Fujio Kayama, Reiko Kishi, Yukihiro Ohya, Hirohisa Saito, Haruhiko Sago, Makiko Okuyama, Tsutomu Ogata, Susumu Yokoya, Yuji Koresawa, Yasuyuki Shibata, Shoji Nakayama, Takehiro Michikawa, Ayano Takeuchi & 1 others Hiroshi Satoh

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Background: There is global concern over significant threats from a wide variety of environmental hazards to which children face. Large-scale and long-term birth cohort studies are needed for better environmental management based on sound science. The primary objective of the Japan Environment and Children's Study (JECS), a nation-wide birth cohort study that started its recruitment in January 2011, is to elucidate environmental factors that affect children's health and development. Methods/Design. Approximately 100,000 expecting mothers who live in designated study areas will be recruited over a 3-year period from January 2011. Participating children will be followed until they reach 13 years of age. Exposure to environmental factors will be assessed by chemical analyses of bio-specimens (blood, cord blood, urine, breast milk, and hair), household environment measurements, and computational simulations using monitoring data (e.g. ambient air quality monitoring) as well as questionnaires. JECS' priority outcomes include reproduction/pregnancy complications, congenital anomalies, neuropsychiatric disorders, immune system disorders, and metabolic/endocrine system disorders. Genetic factors, socioeconomic status, and lifestyle factors will also be examined as covariates and potential confounders. To maximize representativeness, we adopted provider-mediated community-based recruitment. Discussion. Through JECS, chemical substances to which children are exposed during the fetal stage or early childhood will be identified. The JECS results will be translated to better risk assessment and management to provide healthy environment for next generations.

Original languageEnglish
Article number25
JournalBMC Public Health
Volume14
Issue number1
DOIs
Publication statusPublished - 2014 Jan 10
Externally publishedYes

Fingerprint

Environment Design
Japan
Cohort Studies
Term Birth
Endocrine System
Pregnancy Complications
Immune System Diseases
Environmental Exposure
Risk Management
Human Milk
Child Development
Fetal Blood
Social Class
Hair
Reproduction
Life Style
Immune System
Air
Mothers
Outcome Assessment (Health Care)

Keywords

  • Birth cohort
  • Children
  • Environmental chemicals
  • Growth and development
  • Pregnant women

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Kawamoto, T., Nitta, H., Murata, K., Toda, E., Tsukamoto, N., Hasegawa, M., ... Satoh, H. (2014). Rationale and study design of the Japan environment and children's study (JECS). BMC Public Health, 14(1), [25]. https://doi.org/10.1186/1471-2458-14-25

Rationale and study design of the Japan environment and children's study (JECS). / Kawamoto, Toshihiro; Nitta, Hiroshi; Murata, Katsuyuki; Toda, Eisaku; Tsukamoto, Naoya; Hasegawa, Manabu; Yamagata, Zentaro; Kayama, Fujio; Kishi, Reiko; Ohya, Yukihiro; Saito, Hirohisa; Sago, Haruhiko; Okuyama, Makiko; Ogata, Tsutomu; Yokoya, Susumu; Koresawa, Yuji; Shibata, Yasuyuki; Nakayama, Shoji; Michikawa, Takehiro; Takeuchi, Ayano; Satoh, Hiroshi.

In: BMC Public Health, Vol. 14, No. 1, 25, 10.01.2014.

Research output: Contribution to journalArticle

Kawamoto, T, Nitta, H, Murata, K, Toda, E, Tsukamoto, N, Hasegawa, M, Yamagata, Z, Kayama, F, Kishi, R, Ohya, Y, Saito, H, Sago, H, Okuyama, M, Ogata, T, Yokoya, S, Koresawa, Y, Shibata, Y, Nakayama, S, Michikawa, T, Takeuchi, A & Satoh, H 2014, 'Rationale and study design of the Japan environment and children's study (JECS)', BMC Public Health, vol. 14, no. 1, 25. https://doi.org/10.1186/1471-2458-14-25
Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M et al. Rationale and study design of the Japan environment and children's study (JECS). BMC Public Health. 2014 Jan 10;14(1). 25. https://doi.org/10.1186/1471-2458-14-25
Kawamoto, Toshihiro ; Nitta, Hiroshi ; Murata, Katsuyuki ; Toda, Eisaku ; Tsukamoto, Naoya ; Hasegawa, Manabu ; Yamagata, Zentaro ; Kayama, Fujio ; Kishi, Reiko ; Ohya, Yukihiro ; Saito, Hirohisa ; Sago, Haruhiko ; Okuyama, Makiko ; Ogata, Tsutomu ; Yokoya, Susumu ; Koresawa, Yuji ; Shibata, Yasuyuki ; Nakayama, Shoji ; Michikawa, Takehiro ; Takeuchi, Ayano ; Satoh, Hiroshi. / Rationale and study design of the Japan environment and children's study (JECS). In: BMC Public Health. 2014 ; Vol. 14, No. 1.
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