RBC Flow Imaging and pO2 Measurement in Cerebral Microcirculation: Effect of Hemodilution on Oxygen Supply to Brain Cortical Arterioles

Tsunenori Arai, Kosuke Tsukada, E. Sekizuka, C. Oshio, S. Terao, K. Hase, H. Minamitani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hemodilution is still one of the taken therapy in stroke due to increase in cardiac output and decrease in blood viscosity. However, it is not clear the effect of a decrease in oxygen carrying capacity on oxygen supplying to the brain. The aim of this study is to seek the effect of isovolemic hemodilution on oxygen supply. We observed RBC flow rate and oxygen tension pO2 on brain cortical arterioles by using closed cranial window, high-speed videomicroscopy and oxygen dependent quenching of phosphorescence technique. The result showed that RBC flow rate increased about four times from base line and pO2 values were kept within a arteliolar biological state (about a range from 70 to 90mmHg) until Hb was about 10g/dl, respectively. And more severe hemodilution made the both values decrease acutely. The results suggest the increase of RBC flow caused by isovolemic hemodilution keeps supplying oxygen to the brain cortex as low as Hb is 10g/dl.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages1054-1057
Number of pages4
Volume2
Publication statusPublished - 2003
EventA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: 2003 Sep 172003 Sep 21

Other

OtherA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryMexico
CityCancun
Period03/9/1703/9/21

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Keywords

  • Arterioles pO
  • Brain cortex
  • Cerebral blood flow
  • Hemodilution
  • Microcirculation

ASJC Scopus subject areas

  • Bioengineering

Cite this

Arai, T., Tsukada, K., Sekizuka, E., Oshio, C., Terao, S., Hase, K., & Minamitani, H. (2003). RBC Flow Imaging and pO2 Measurement in Cerebral Microcirculation: Effect of Hemodilution on Oxygen Supply to Brain Cortical Arterioles. In R. S. Leder (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 1054-1057)