RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles

Takuya Tashiro, Yasuyuki Ishii, Tomokuni Shigeura, Ryusuke Nakagawa, Hiroshi Watarai, Masaru Taniguchi, Kenji Mori

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

α-Galactosphingolipid analogues of KRN7000 with a sulfonamide (RCAI-39), a carbamate (RCAI-41), an α,α-difluorocarboxamide (RCAI-100) or an N-methylcarboxamide linkage (RCAI-127) instead of a carboxamide bond of KRN7000 were synthesized. Their bioactivities for mouse natural killer T cells were examined. Bioactivities of truncated analogues, OCH and RCAI-53, and β-galactosphingolipid (RCAI-128) were also examined. All of these glycosphingolipids induced Th2-biased cytokine production by their administration as liposomal particles. Among them, liposomes containing RCAI-127 induced the most potent Th2-biased response.

Original languageEnglish
Pages (from-to)620-625
Number of pages6
JournalMedChemComm
Volume2
Issue number7
DOIs
Publication statusPublished - 2011 Jul
Externally publishedYes

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Natural Killer T-Cells
T-cells
Bioactivity
Cytokines
Glycosphingolipids
Carbamates
Sulfonamides
Liposomes
KRN 7000

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles. / Tashiro, Takuya; Ishii, Yasuyuki; Shigeura, Tomokuni; Nakagawa, Ryusuke; Watarai, Hiroshi; Taniguchi, Masaru; Mori, Kenji.

In: MedChemComm, Vol. 2, No. 7, 07.2011, p. 620-625.

Research output: Contribution to journalArticle

Tashiro, Takuya ; Ishii, Yasuyuki ; Shigeura, Tomokuni ; Nakagawa, Ryusuke ; Watarai, Hiroshi ; Taniguchi, Masaru ; Mori, Kenji. / RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles. In: MedChemComm. 2011 ; Vol. 2, No. 7. pp. 620-625.
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