Re-elevation of d-dimer as a predictor of re-dissection and venous thromboembolism after Stanford type B acute aortic dissection

Yusuke Jo, Toshihisa Anzai, Koji Ueno, Hidehiro Kaneko, Takashi Kohno, Yasuo Sugano, Yuichiro Maekawa, Tsutomu Yoshikawa, Hideyuki Shimizu, Ryohei Yozu, Satoshi Ogawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

d-dimer measurement is a useful complementary initial diagnostic marker in patients with acute aortic dissection (AAD). However, it has not been clarified whether serial measurements of d-dimer are useful during in-hospital management of Stanford type B AAD. We studied 30 patients who were admitted with diagnosis of Stanford type B AAD and treated conservatively. d-dimer was serially measured on admission and then every 5 days during hospitalization. Patients were divided into two groups according to the presence or absence of re-elevation of d-dimer during hospitalization, in which d-dimer transition were biphasic and latter peak >10.0 μg/ml. Re-elevation of d-dimer was observed in 17 patients. There were no differences in atherosclerotic risk factors, blood pressure on admission, d-dimer level on admission, extent of AAD, and false lumen patency. Patients with re-elevation of d-dimer showed higher incidence of re-dissection and/or venous thromboembolism (VTE). Peak d-dimer level in patients with re-dissection and/or VTE was significantly higher than that without these complications (p = 0.005). In conclusion, serial measurements of d-dimer are useful for early detection of re-dissection or VTE in patients with Stanford type B AAD, which may contribute to the prevention of disastrous consequences such as pulmonary embolism and extension of AAD.

Original languageEnglish
Pages (from-to)509-514
Number of pages6
JournalHeart and Vessels
Volume25
Issue number6
DOIs
Publication statusPublished - 2010 Nov

Fingerprint

Venous Thromboembolism
Dissection
Hospitalization
Pulmonary Embolism
Blood Pressure
Incidence

Keywords

  • Aorta
  • Biomarkers
  • Complications
  • Dissection
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Re-elevation of d-dimer as a predictor of re-dissection and venous thromboembolism after Stanford type B acute aortic dissection. / Jo, Yusuke; Anzai, Toshihisa; Ueno, Koji; Kaneko, Hidehiro; Kohno, Takashi; Sugano, Yasuo; Maekawa, Yuichiro; Yoshikawa, Tsutomu; Shimizu, Hideyuki; Yozu, Ryohei; Ogawa, Satoshi.

In: Heart and Vessels, Vol. 25, No. 6, 11.2010, p. 509-514.

Research output: Contribution to journalArticle

Jo, Y, Anzai, T, Ueno, K, Kaneko, H, Kohno, T, Sugano, Y, Maekawa, Y, Yoshikawa, T, Shimizu, H, Yozu, R & Ogawa, S 2010, 'Re-elevation of d-dimer as a predictor of re-dissection and venous thromboembolism after Stanford type B acute aortic dissection', Heart and Vessels, vol. 25, no. 6, pp. 509-514. https://doi.org/10.1007/s00380-010-0028-x
Jo, Yusuke ; Anzai, Toshihisa ; Ueno, Koji ; Kaneko, Hidehiro ; Kohno, Takashi ; Sugano, Yasuo ; Maekawa, Yuichiro ; Yoshikawa, Tsutomu ; Shimizu, Hideyuki ; Yozu, Ryohei ; Ogawa, Satoshi. / Re-elevation of d-dimer as a predictor of re-dissection and venous thromboembolism after Stanford type B acute aortic dissection. In: Heart and Vessels. 2010 ; Vol. 25, No. 6. pp. 509-514.
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