The limited attentional resource of users is a bottleneck to delivery of push notifications in today's mobile and ubiquitous computing environments. Adaptive mobile notification scheduling, which detects opportune timings based on mobile sensing and machine learning, has been proposed as a way of alleviating this problem. However, it is still not clear if such adaptive notifications are effective in a large-scale product deployment with real-world situations and configurations, such as users' context changes, personalized content in notifications, and sudden external factors that users commonly experience (such as breaking news). In this paper, we construct a new interruptibility estimation and adaptive notification scheduling with redesigned technical components. From the deploy study of the system to the real product stack of Yahoo! JAPAN Android application and evaluation with 382,518 users for 28 days, we confirmed several significant results, including the maximum 60.7% increase in the users' click rate, 10 times more gain1compared to the previous system, significantly better gain in the personalized notification content, and unexpectedly better performance in a situation with exceptional breaking news notifications. With these results, the proposed system has officially been deployed and enabled to all the users of Yahoo! JAPAN product environment where more than 10 million Android app users are enjoying its benefit.