Rearrangement of immunoglobulin k gene in a variant-type burkitt lymphoma cell line, kobk101, carrying a translocation between chromosomes 2 and 8

Masami Fujino, Nobuyuki Takayama, Shingo Kato, Koichi Matsuo, Toshiya Takano, Shinpei Nakazawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The immunoglobulin k light-chain gene was rearranged in a Burkitt lymphoma cell line with the t(2;8) (p11;q24) translocation, KOBK101, showing recombination between the variable and the joining regions on one allele and an aberrant substitution of the region upstream of the J5 segment with an unknown sequence on another allele. Because DNA segments homologous to the consensus sequences of joining and switching regions of immunoglobulin genes were detected in the unknown sequence, we speculate that the system for either V-J or switching recombination in immunoglobulin genes may be involved in forming this unusual rearrangement.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalJapanese Journal of Cancer Research GANN
Volume77
Issue number1
Publication statusPublished - 1986 Jan 1

    Fingerprint

Keywords

  • C region
  • Nucleotide sequences
  • Southern blot analysis
  • V-J recombination
  • c-myc

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this