Rearrangement of immunoglobulin k gene in a variant-type burkitt lymphoma cell line, kobk101, carrying a translocation between chromosomes 2 and 8

Masami Fujino; Nobuyuki Takayama; Shingo Kato; Koichi Matsuo; Toshiya Takano; Shinpei Nakazawa

Rearrangement of immunoglobulin k gene in a variant-type burkitt lymphoma cell line, kobk101, carrying a translocation between chromosomes 2 and 8

Masami Fujino, Nobuyuki Takayama, Shingo Kato, Koichi Matsuo, Toshiya Takano, Shinpei Nakazawa

Research output: Contribution to journal › Article › peer-review

Abstract

The immunoglobulin k light-chain gene was rearranged in a Burkitt lymphoma cell line with the t(2;8) (p11;q24) translocation, KOBK101, showing recombination between the variable and the joining regions on one allele and an aberrant substitution of the region upstream of the J5 segment with an unknown sequence on another allele. Because DNA segments homologous to the consensus sequences of joining and switching regions of immunoglobulin genes were detected in the unknown sequence, we speculate that the system for either V-J or switching recombination in immunoglobulin genes may be involved in forming this unusual rearrangement.

Original language	English
Pages (from-to)	24-27
Number of pages	4
Journal	Japanese Journal of Cancer Research GANN
Volume	77
Issue number	1
Publication status	Published - 1986 Jan 1

Keywords

C region
Nucleotide sequences
Southern blot analysis
V-J recombination
c-myc

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The immunoglobulin k light-chain gene was rearranged in a Burkitt lymphoma cell line with the t(2;8) (p11;q24) translocation, KOBK101, showing recombination between the variable and the joining regions on one allele and an aberrant substitution of the region upstream of the J5 segment with an unknown sequence on another allele. Because DNA segments homologous to the consensus sequences of joining and switching regions of immunoglobulin genes were detected in the unknown sequence, we speculate that the system for either V-J or switching recombination in immunoglobulin genes may be involved in forming this unusual rearrangement.",

keywords = "C region, Nucleotide sequences, Southern blot analysis, V-J recombination, c-myc",

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T1 - Rearrangement of immunoglobulin k gene in a variant-type burkitt lymphoma cell line, kobk101, carrying a translocation between chromosomes 2 and 8

AU - Fujino, Masami

AU - Takayama, Nobuyuki

AU - Kato, Shingo

AU - Matsuo, Koichi

AU - Takano, Toshiya

AU - Nakazawa, Shinpei

PY - 1986/1/1

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N2 - The immunoglobulin k light-chain gene was rearranged in a Burkitt lymphoma cell line with the t(2;8) (p11;q24) translocation, KOBK101, showing recombination between the variable and the joining regions on one allele and an aberrant substitution of the region upstream of the J5 segment with an unknown sequence on another allele. Because DNA segments homologous to the consensus sequences of joining and switching regions of immunoglobulin genes were detected in the unknown sequence, we speculate that the system for either V-J or switching recombination in immunoglobulin genes may be involved in forming this unusual rearrangement.

AB - The immunoglobulin k light-chain gene was rearranged in a Burkitt lymphoma cell line with the t(2;8) (p11;q24) translocation, KOBK101, showing recombination between the variable and the joining regions on one allele and an aberrant substitution of the region upstream of the J5 segment with an unknown sequence on another allele. Because DNA segments homologous to the consensus sequences of joining and switching regions of immunoglobulin genes were detected in the unknown sequence, we speculate that the system for either V-J or switching recombination in immunoglobulin genes may be involved in forming this unusual rearrangement.

KW - C region

KW - Nucleotide sequences

KW - Southern blot analysis

KW - V-J recombination

KW - c-myc

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SN - 1347-9032

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Rearrangement of immunoglobulin k gene in a variant-type burkitt lymphoma cell line, kobk101, carrying a translocation between chromosomes 2 and 8

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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