Recent advances in boron-mediated aglycon delivery (BMAD) for the efficient synthesis of 1,2-cis glycosides

Research output: Contribution to journalShort surveypeer-review

Abstract

Highly stereoselective synthesis of 1,2-cis glycosides remains a challenging task due to the lack of reliable neighboring group participation (NGP) from the 2-O-acyl functionality in the glycosyl donor. In this context, our group recently developed highly 1,2-cis-stereoselective glycosylation methods, named boron-mediated aglycon delivery (BMAD), using organoboron reagents and 1,2-anhydroglycosyl donors. In this mini-review article, we introduce the BMAD methods and their applications to the synthesis of biologically active natural products and complex glycosides reported since our mini-review article published in this journal in 2017.

Original languageEnglish
Article number108579
JournalCarbohydrate Research
Volume518
DOIs
Publication statusPublished - 2022 Aug

Keywords

  • 1,2-cis glycoside
  • Boron-mediated aglycon delivery
  • Glycosylation
  • Natural products
  • Regioselective
  • Stereoselective

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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