Recent advances in cardiovascular regenerative medicine

The induced pluripotent stem cell era

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Induced pluripotent stem (iPS) cells have recently been established by transfecting mouse and human fibroblasts with the transcription factors Oct3/4, Sox2, Klf4 and c-Myc, known to be expressed at high levels in embryonic stem (ES) cells. These cells have great potential in regenerative medicine as they have the capacity to differentiate into all three germ layer-derived cells and are syngeneic. The differentiation of ES cells into cardiomyocytes mimics the early processes involved in heart development. Recent studies describe the contribution of various growth factors and corresponding inhibitors to heart development during embryogenesis. Bone morphogenetic proteins, Wnt protein and Notch signals play critical roles in heart development in a context- and time-dependent manner. Consistent with ES cells, the exposure of iPS cells to such growth factors is hypothesized to augment differentiation into cardiomyocytes. The combination of iPS cells and appropriate developmental signal information has the potential for providing the foundations for future regenerative medicine.

Original languageEnglish
Pages (from-to)803-810
Number of pages8
JournalExpert Review of Cardiovascular Therapy
Volume6
Issue number6
DOIs
Publication statusPublished - 2008 Jul

Fingerprint

Induced Pluripotent Stem Cells
Regenerative Medicine
Embryonic Stem Cells
Cardiac Myocytes
Intercellular Signaling Peptides and Proteins
Wnt Proteins
Germ Layers
Bone Morphogenetic Proteins
Embryonic Development
Transcription Factors
Fibroblasts

Keywords

  • Cardiomyocyte
  • Embryonic stem cell
  • Heart
  • Induced pluripotent stem cell
  • iPS
  • Regenerative medicine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

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abstract = "Induced pluripotent stem (iPS) cells have recently been established by transfecting mouse and human fibroblasts with the transcription factors Oct3/4, Sox2, Klf4 and c-Myc, known to be expressed at high levels in embryonic stem (ES) cells. These cells have great potential in regenerative medicine as they have the capacity to differentiate into all three germ layer-derived cells and are syngeneic. The differentiation of ES cells into cardiomyocytes mimics the early processes involved in heart development. Recent studies describe the contribution of various growth factors and corresponding inhibitors to heart development during embryogenesis. Bone morphogenetic proteins, Wnt protein and Notch signals play critical roles in heart development in a context- and time-dependent manner. Consistent with ES cells, the exposure of iPS cells to such growth factors is hypothesized to augment differentiation into cardiomyocytes. The combination of iPS cells and appropriate developmental signal information has the potential for providing the foundations for future regenerative medicine.",
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