Recent advances in catalytic asymmetric CC bond-forming reactions to ketimines promoted by metal-based catalysts

Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

Recent progress (post-2010) in the field of metal-catalyzed asymmetric CC bond-forming reactions using ketimines as electrophiles is reviewed. Compared with the corresponding aldimines, ketimines generally display less inherent reactivity and the two substituents on the imine carbon hamper prochiral-face-selection for enantioselective reactions. Recent advances with newly developed catalytic systems have resulted in several solutions to these long-standing problems. The construction of tetrasubstituted stereogenic centers is a crucial topic of asymmetric catalysis in the 21st century, and it is becoming increasingly clear that reactions using ketimines as electrophiles become one of the most important routes to access such chemical entities.

Original languageEnglish
Pages (from-to)503-517
Number of pages15
JournalBulletin of the Chemical Society of Japan
Volume88
Issue number4
DOIs
Publication statusPublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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