Recent advances in direct catalytic asymmetric transformations under proton-transfer conditions

Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

138 Citations (Scopus)

Abstract

Cooperative catalysis has proven to be a particularly powerful strategy for promoting stereoselective organic transformations under mild reaction conditions. The specific interactions between the catalyst components and substrates are precisely orchestrated to elicit high catalytic efficiency and excellent control of the stereochemical course. By harnessing the power of cooperativity, various sets of stereoselective reactions proceed under mild proton-transfer conditions with perfect atom economy. This Minireview summarizes our recent contributions to several C-N and C-C bond-forming reactions in this field and related transformations. Give me an H: The sophisticated synergism of the two concepts of asymmetric catalysis and atom economy offers a truly efficient synthetic strategy for the production of requisite chemical entities with high enantiomeric purity. Recent advances in this field are highlighted, with a particular emphasis on catalytic asymmetric reactions that proceeds under proton-transfer conditions.

Original languageEnglish
Pages (from-to)4760-4772
Number of pages13
JournalAngewandte Chemie - International Edition
Volume50
Issue number21
DOIs
Publication statusPublished - 2011 May 16
Externally publishedYes

Keywords

  • asymmetric catalysis
  • atom economy
  • cooperative effects
  • proton transfer
  • tetrasubstituted stereogenic centers

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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