Recent advances in rare earth metal asymmetric catalysis toward practical synthesis of therapeutics

Naoya Kumagai; Masakatsu Shibasaki

doi:10.1007/978-981-10-3421-3_1

Recent advances in rare earth metal asymmetric catalysis toward practical synthesis of therapeutics

Naoya Kumagai, Masakatsu Shibasaki

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Two case studies regarding the development of rare earth metal-based asymmetric catalysts are summarized, with particular focus on the process of refining catalysts amenable to industrial applications. Amide-based chiral ligands in combination with lanthanum or neodymium cations furnished robust catalytic systems for asymmetric amination or nitroaldol reactions, respectively. Although rare earth metal catalysis is generally characterized by a peculiar coordination chemistry and Lewis acidic catalytic functions, its wide availability and moderate tolerance to moisture are also important features to be noted, making the application of rare earth metal catalysis beneficial for industrial large-scale synthesis.

Original language	English
Title of host publication	New Horizons of Process Chemistry
Subtitle of host publication	Scalable Reactions and Technologies
Publisher	Springer Singapore
Pages	1-10
Number of pages	10
ISBN (Electronic)	9789811034213
ISBN (Print)	9789811034206
DOIs	https://doi.org/10.1007/978-981-10-3421-3_1
Publication status	Published - 2017 Jan 1
Externally published	Yes

Keywords

Amination
Asymmetric catalysis
Flow reaction
Nitroaldol
Rare earth metals

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Medicine(all)
Engineering(all)
Agricultural and Biological Sciences(all)

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10.1007/978-981-10-3421-3_1

Cite this

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AB - Two case studies regarding the development of rare earth metal-based asymmetric catalysts are summarized, with particular focus on the process of refining catalysts amenable to industrial applications. Amide-based chiral ligands in combination with lanthanum or neodymium cations furnished robust catalytic systems for asymmetric amination or nitroaldol reactions, respectively. Although rare earth metal catalysis is generally characterized by a peculiar coordination chemistry and Lewis acidic catalytic functions, its wide availability and moderate tolerance to moisture are also important features to be noted, making the application of rare earth metal catalysis beneficial for industrial large-scale synthesis.

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Recent advances in rare earth metal asymmetric catalysis toward practical synthesis of therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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