Recent advances in rare earth metal asymmetric catalysis toward practical synthesis of therapeutics

Naoya Kumagai, Masakatsu Shibasaki

Research output: Chapter in Book/Report/Conference proceedingChapter


Two case studies regarding the development of rare earth metal-based asymmetric catalysts are summarized, with particular focus on the process of refining catalysts amenable to industrial applications. Amide-based chiral ligands in combination with lanthanum or neodymium cations furnished robust catalytic systems for asymmetric amination or nitroaldol reactions, respectively. Although rare earth metal catalysis is generally characterized by a peculiar coordination chemistry and Lewis acidic catalytic functions, its wide availability and moderate tolerance to moisture are also important features to be noted, making the application of rare earth metal catalysis beneficial for industrial large-scale synthesis.

Original languageEnglish
Title of host publicationNew Horizons of Process Chemistry
Subtitle of host publicationScalable Reactions and Technologies
PublisherSpringer Singapore
Number of pages10
ISBN (Electronic)9789811034213
ISBN (Print)9789811034206
Publication statusPublished - 2017 Jan 1
Externally publishedYes


  • Amination
  • Asymmetric catalysis
  • Flow reaction
  • Nitroaldol
  • Rare earth metals

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Medicine(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)


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