Recent advances in sentinel node navigation for gastric cancer: A paradigm shift of surgical management

Yuukou Kitagawa, Hirofumi Fujii, Koichiro Kumai, Tetsuro Kubota, Yoshihide Otani, Yoshiro Saikawa, Masashi Yoshida, Atsushi Kubo, Masaki Kitajima

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The sentinel node (SN) is defined as the first draining node from the primary lesion and it has proven to be a good indicator of the metastatic status of regional lymph nodes in solid tumors. In the past 5 years, the validity of SN concept for gastric cancer has been demonstrated by a number of single institutional studies. Using a dual tracer method as the optimal procedure, the radio-guided method allows us to confirm the complete harvest of SNs by gamma probing, while the dye procedure enables us to perform real time observation of the lymphatic vessels. From previous reports, clinically staged T1N0 gastric cancer seems to be a good entity on which to try to change the therapeutic approach based on SN biopsy. At present, two large scale prospective multi-center trials are on-going in Japan. To overcome some remaining issues, such as limited sensitivity of intra-operative diagnosis of metastasis, and technical difficulty in laparoscopic SN detection, further technical and instrumental developments will be required. During this transitional phase, focused lymph node dissection targeted to sentinel lymphatic basins and modified resection of the stomach is an acceptable approach. Although there are several remaining issues, SN navigation should provide a paradigm shift for the surgical management of early gastric cancer in near future.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalJournal of Surgical Oncology
Volume90
Issue number3
DOIs
Publication statusPublished - 2005 Jun 1

Fingerprint

Stomach Neoplasms
Lymphatic Vessels
Lymph Node Excision
Radio
cyhalothrin
Stomach
Japan
Coloring Agents
Lymph Nodes
Observation
Neoplasm Metastasis
Biopsy
Neoplasms

Keywords

  • Gastric cancer
  • Laparoscopic surgery
  • Micrometastasis
  • Minimally invasive surgery
  • Sentinel node

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Recent advances in sentinel node navigation for gastric cancer : A paradigm shift of surgical management. / Kitagawa, Yuukou; Fujii, Hirofumi; Kumai, Koichiro; Kubota, Tetsuro; Otani, Yoshihide; Saikawa, Yoshiro; Yoshida, Masashi; Kubo, Atsushi; Kitajima, Masaki.

In: Journal of Surgical Oncology, Vol. 90, No. 3, 01.06.2005, p. 147-151.

Research output: Contribution to journalArticle

Kitagawa, Y, Fujii, H, Kumai, K, Kubota, T, Otani, Y, Saikawa, Y, Yoshida, M, Kubo, A & Kitajima, M 2005, 'Recent advances in sentinel node navigation for gastric cancer: A paradigm shift of surgical management', Journal of Surgical Oncology, vol. 90, no. 3, pp. 147-151. https://doi.org/10.1002/jso.20220
Kitagawa, Yuukou ; Fujii, Hirofumi ; Kumai, Koichiro ; Kubota, Tetsuro ; Otani, Yoshihide ; Saikawa, Yoshiro ; Yoshida, Masashi ; Kubo, Atsushi ; Kitajima, Masaki. / Recent advances in sentinel node navigation for gastric cancer : A paradigm shift of surgical management. In: Journal of Surgical Oncology. 2005 ; Vol. 90, No. 3. pp. 147-151.
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