Recent advances in the synthesis of morphine and related alkaloids

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26 Citations (Scopus)

Abstract

Morphine, an alkaloid isolated from the opium poppy, has been widely used as an analgesic, and has been a fascinating synthetic target of organic chemists. After the first total synthesis reported in 1952, a number of synthetic studies toward morphine have been reported, and findings obtained in such studies have greatly contributed to the progress of synthetic organic chemistry as well as medicinal chemistry. This review provides an overview of recent studies toward the total synthesis of morphine and related alkaloids. Work reported in the literature since 2004 will be reviewed.

Original languageEnglish
Title of host publicationChemistry of Opioids
EditorsHiroshi Nagase
Pages1-28
Number of pages28
DOIs
Publication statusPublished - 2011 Feb 4

Publication series

NameTopics in Current Chemistry
Volume299
ISSN (Print)0340-1022

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Keywords

  • Chiral synthesis
  • Codeine
  • Morphine
  • Total synthesis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Chida, N. (2011). Recent advances in the synthesis of morphine and related alkaloids. In H. Nagase (Ed.), Chemistry of Opioids (pp. 1-28). (Topics in Current Chemistry; Vol. 299). https://doi.org/10.1007/128_2010_73