Abstract
Utilization of biocatalysts with high accessibility and availability, which have recently been applied in the preparation of enantiomerically enriched starting materials and synthetic intermediates for natural product syntheses (mainly 2013–2017) are summarized in this review. The main contents are as follows: 1) recruitment of biocatalysts for the transformation of organic compounds; 2) special precautions for preparative-scale biocatalytic synthetic experiments; 3) asymmetric reduction of carbonyl substrates; 4) kinetic resolution of alcohol and carboxylate enantiomers; 5) desymmetrization of multifunctional alcohol and carboxylate substrates; and 6) recognition of remote and non-central chirality.
| Original language | English |
|---|---|
| Pages (from-to) | 3469-3487 |
| Number of pages | 19 |
| Journal | Tetrahedron |
| Volume | 74 |
| Issue number | 27 |
| DOIs | |
| Publication status | Published - 2018 Jul 5 |
Keywords
- Acylation
- Asymmetric reduction
- Carbonyl
- Desymmetrization
- Esterase
- Hydrolysis
- Kinetic resolution
- Lipase
- Natural product synthesis
- Reductase
- Whole-cell biocatalyst
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry