Recent examples of the use of biocatalysts with high accessibility and availability in natural product synthesis

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Abstract

Utilization of biocatalysts with high accessibility and availability, which have recently been applied in the preparation of enantiomerically enriched starting materials and synthetic intermediates for natural product syntheses (mainly 2013–2017) are summarized in this review. The main contents are as follows: 1) recruitment of biocatalysts for the transformation of organic compounds; 2) special precautions for preparative-scale biocatalytic synthetic experiments; 3) asymmetric reduction of carbonyl substrates; 4) kinetic resolution of alcohol and carboxylate enantiomers; 5) desymmetrization of multifunctional alcohol and carboxylate substrates; and 6) recognition of remote and non-central chirality.

Original languageEnglish
JournalTetrahedron
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Keywords

  • Acylation
  • Asymmetric reduction
  • Carbonyl
  • Desymmetrization
  • Esterase
  • Hydrolysis
  • Kinetic resolution
  • Lipase
  • Natural product synthesis
  • Reductase
  • Whole-cell biocatalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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