Receptor tyrosine kinases involved in hematopoietic progenitor cells

T. Suda, A. Iwama, M. Hashiyama, S. Sakano, M. Ohno

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To analyze the molecular mechanisms of the proliferation and differentiation of hematopoietic cells, we have cloned PTKs from sorted stem cells. We discuss the expression and function of receptor tyrosine kinases, STK/RON, TIE, TEK and HTK which have been cloned from these cells. STK and its ligand, MSP contributed to the motility and phagocytosis of peritoneal macrophages and bone absorption of osteoclasts. Apoptosis was induced in an erythrorid cell line by the binding of MSP (Macrophage Stimulating Protein). TIE, TEK and HTK were interestingly expressed in the subpopulations of stem cells and related to the myeloid differentiation. These study will indicate the heterogeneity of stem cells and their diverse differentiation.

Original languageEnglish
Pages (from-to)451-453
Number of pages3
JournalLeukemia
Volume11
Issue numberSUPPL. 3
Publication statusPublished - 1997

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Receptor Protein-Tyrosine Kinases
Hematopoietic Stem Cells
Stem Cells
Peritoneal Macrophages
Osteoclasts
Phagocytosis
Cell Differentiation
Apoptosis
Ligands
Bone and Bones
Cell Line
macrophage stimulating protein

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Suda, T., Iwama, A., Hashiyama, M., Sakano, S., & Ohno, M. (1997). Receptor tyrosine kinases involved in hematopoietic progenitor cells. Leukemia, 11(SUPPL. 3), 451-453.

Receptor tyrosine kinases involved in hematopoietic progenitor cells. / Suda, T.; Iwama, A.; Hashiyama, M.; Sakano, S.; Ohno, M.

In: Leukemia, Vol. 11, No. SUPPL. 3, 1997, p. 451-453.

Research output: Contribution to journalArticle

Suda, T, Iwama, A, Hashiyama, M, Sakano, S & Ohno, M 1997, 'Receptor tyrosine kinases involved in hematopoietic progenitor cells', Leukemia, vol. 11, no. SUPPL. 3, pp. 451-453.
Suda T, Iwama A, Hashiyama M, Sakano S, Ohno M. Receptor tyrosine kinases involved in hematopoietic progenitor cells. Leukemia. 1997;11(SUPPL. 3):451-453.
Suda, T. ; Iwama, A. ; Hashiyama, M. ; Sakano, S. ; Ohno, M. / Receptor tyrosine kinases involved in hematopoietic progenitor cells. In: Leukemia. 1997 ; Vol. 11, No. SUPPL. 3. pp. 451-453.
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