Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes

S. L. Topalian, S. S. Hom, Yutaka Kawakami, M. Mancini, D. J. Schwartzentruber, R. Zakut, S. A. Rosenberg

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have established that melanomas express shared tumor antigens (Ags) that can be recognized by T cells if presented in the context of self-MHC molecules. Tumor-infiltrating lymphocytes (TILs) from six melanoma patients were tested for lysis of large panels of HLA-matched or unmatched targets representing a variety of tissue types. Lysis was specific for allogeneic melanomas sharing at least one HLA-A, -B, or -C Ag with TILs, and demonstrated commonly expressed tumor Ags. Similar findings were obtained when cytokine secretion by TILs was used to indicate specific Ag recognition. Transfection of the HLA-A2.1 gene into HLA-A2 melanoma lines conferred susceptibility to lysis by HLA-A2 restricted melanoma TILs, demonstrating expression of common tumor Ags among patients of diverse HLA types. These findings have important implications for developing broadly applicable cancer immunotherapies such as vaccines.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalJournal of Immunotherapy
Volume12
Issue number3
DOIs
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Melanoma-Specific Antigens
Tumor-Infiltrating Lymphocytes
Melanoma
Neoplasm Antigens
HLA-A2 Antigen
HLA-A Antigens
HLA-B Antigens
Immunotherapy
Transfection
Vaccines
Cytokines
T-Lymphocytes
Genes
Neoplasms

Keywords

  • Melanoma
  • Tumor-infiltrating lymphocytes
  • Tumor-specific antigens

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Immunology

Cite this

Topalian, S. L., Hom, S. S., Kawakami, Y., Mancini, M., Schwartzentruber, D. J., Zakut, R., & Rosenberg, S. A. (1992). Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes. Journal of Immunotherapy, 12(3), 203-206. https://doi.org/10.1097/00002371-199210000-00013

Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes. / Topalian, S. L.; Hom, S. S.; Kawakami, Yutaka; Mancini, M.; Schwartzentruber, D. J.; Zakut, R.; Rosenberg, S. A.

In: Journal of Immunotherapy, Vol. 12, No. 3, 1992, p. 203-206.

Research output: Contribution to journalArticle

Topalian, SL, Hom, SS, Kawakami, Y, Mancini, M, Schwartzentruber, DJ, Zakut, R & Rosenberg, SA 1992, 'Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes', Journal of Immunotherapy, vol. 12, no. 3, pp. 203-206. https://doi.org/10.1097/00002371-199210000-00013
Topalian SL, Hom SS, Kawakami Y, Mancini M, Schwartzentruber DJ, Zakut R et al. Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes. Journal of Immunotherapy. 1992;12(3):203-206. https://doi.org/10.1097/00002371-199210000-00013
Topalian, S. L. ; Hom, S. S. ; Kawakami, Yutaka ; Mancini, M. ; Schwartzentruber, D. J. ; Zakut, R. ; Rosenberg, S. A. / Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes. In: Journal of Immunotherapy. 1992 ; Vol. 12, No. 3. pp. 203-206.
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