Abstract
Immune cells, including lymphocytes, express muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs, respectively), and agonist stimulation of these AChRs causes functional and biochemical changes in the cells. The origin of the ACh that acts on immune cell AChRs has remained unclear until recently, however. In 1995, we identified choline acetyltransferase mRNA and protein in human T cells, and found that immunological T cell activation potentiated lymphocytic cholinergic transmission by increasing ACh synthesis and AChR expression. We also found that M1/M5 mAChR signaling upregulates IgG1 and proinflammatory cytokine production, whereas α7 nAChR signaling has the opposite effect. These findings suggest that ACh synthesized by T cells acts as an autocrine and/or paracrine factor via AChRs on immune cells to modulate immune function. In addition, a recently discovered endogenous allosteric α7 nAChR ligand, SLURP-1, also appears to be involved in modulating normal T cell function.
| Original language | English |
|---|---|
| Pages (from-to) | 7-17 |
| Number of pages | 11 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1261 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 Jul |
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Keywords
- Choline acetyltransferase
- Cytokine
- MAChR
- NAChR
- SLURP-1
- T cell
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function. / Kawashima, Koichiro; Fujii, Takeshi; Moriwaki, Yasuhiro; Misawa, Hidemi; Horiguchi, Kazuhide.
In: Annals of the New York Academy of Sciences, Vol. 1261, No. 1, 07.2012, p. 7-17.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function
AU - Kawashima, Koichiro
AU - Fujii, Takeshi
AU - Moriwaki, Yasuhiro
AU - Misawa, Hidemi
AU - Horiguchi, Kazuhide
PY - 2012/7
Y1 - 2012/7
N2 - Immune cells, including lymphocytes, express muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs, respectively), and agonist stimulation of these AChRs causes functional and biochemical changes in the cells. The origin of the ACh that acts on immune cell AChRs has remained unclear until recently, however. In 1995, we identified choline acetyltransferase mRNA and protein in human T cells, and found that immunological T cell activation potentiated lymphocytic cholinergic transmission by increasing ACh synthesis and AChR expression. We also found that M1/M5 mAChR signaling upregulates IgG1 and proinflammatory cytokine production, whereas α7 nAChR signaling has the opposite effect. These findings suggest that ACh synthesized by T cells acts as an autocrine and/or paracrine factor via AChRs on immune cells to modulate immune function. In addition, a recently discovered endogenous allosteric α7 nAChR ligand, SLURP-1, also appears to be involved in modulating normal T cell function.
AB - Immune cells, including lymphocytes, express muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs, respectively), and agonist stimulation of these AChRs causes functional and biochemical changes in the cells. The origin of the ACh that acts on immune cell AChRs has remained unclear until recently, however. In 1995, we identified choline acetyltransferase mRNA and protein in human T cells, and found that immunological T cell activation potentiated lymphocytic cholinergic transmission by increasing ACh synthesis and AChR expression. We also found that M1/M5 mAChR signaling upregulates IgG1 and proinflammatory cytokine production, whereas α7 nAChR signaling has the opposite effect. These findings suggest that ACh synthesized by T cells acts as an autocrine and/or paracrine factor via AChRs on immune cells to modulate immune function. In addition, a recently discovered endogenous allosteric α7 nAChR ligand, SLURP-1, also appears to be involved in modulating normal T cell function.
KW - Choline acetyltransferase
KW - Cytokine
KW - MAChR
KW - NAChR
KW - SLURP-1
KW - T cell
UR - http://www.scopus.com/inward/record.url?scp=84864075885&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864075885&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2012.06516.x
DO - 10.1111/j.1749-6632.2012.06516.x
M3 - Article
C2 - 22823388
AN - SCOPUS:84864075885
VL - 1261
SP - 7
EP - 17
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -