Abstract
Introduction: The use of artificial urinary sphincters can improve urinary incontinence after radical prostatectomies; however, complications can arise. We hypothesized that dynamic graciloplasty improves urethral sphincter reconstruction. Materials and Methods: Models of urethral sphincter muscle reconstruction were developed in 5 adult rabbits by wrapping the gracilis muscle flap around the urethra. Intraurethral pressure was measured in each of the models before reconstruction (control), after reconstruction, and after electrical stimulation of the flap in reconstructed models (stimulated models). Results: The mean maximum urethral closure pressure was significantly greater in the reconstruction model (69.7 (66.5-115.8) mm Hg) than in the control model (39.2 (33.7-49.6) mm Hg). The mean integral of the urethral pressure and urethral length was also significantly greater in the reconstruction model than in the control mod-el. Furthermore, sphincter tightening was enhanced by the electrical stimulation of the flap. Conclusions: Our results support our hypothesis that the functional reconstruction of urethral sphincters using muscle flaps is promising for the treatment of urinary incontinence.
| Original language | English |
|---|---|
| Pages (from-to) | 217-222 |
| Number of pages | 6 |
| Journal | Urologia Internationalis |
| Volume | 96 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2016 Feb 1 |
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Keywords
- Dynamic graciloplasty
- Nerve anastomosis
- Pudendal nerve
- Urethral sphincter incompetence
ASJC Scopus subject areas
- Urology
Cite this
Reconstruction of the Urethral Sphincter with Dynamic Graciloplasty in a Male Rabbit Model. / Uchikawa-Tani, Yumiko; Yazawa, Masaki; Sakuma, Hisashi; Hikosaka, Makoto; Takayama, Masayoshi; Kishi, Kazuo.
In: Urologia Internationalis, Vol. 96, No. 2, 01.02.2016, p. 217-222.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reconstruction of the Urethral Sphincter with Dynamic Graciloplasty in a Male Rabbit Model
AU - Uchikawa-Tani, Yumiko
AU - Yazawa, Masaki
AU - Sakuma, Hisashi
AU - Hikosaka, Makoto
AU - Takayama, Masayoshi
AU - Kishi, Kazuo
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Introduction: The use of artificial urinary sphincters can improve urinary incontinence after radical prostatectomies; however, complications can arise. We hypothesized that dynamic graciloplasty improves urethral sphincter reconstruction. Materials and Methods: Models of urethral sphincter muscle reconstruction were developed in 5 adult rabbits by wrapping the gracilis muscle flap around the urethra. Intraurethral pressure was measured in each of the models before reconstruction (control), after reconstruction, and after electrical stimulation of the flap in reconstructed models (stimulated models). Results: The mean maximum urethral closure pressure was significantly greater in the reconstruction model (69.7 (66.5-115.8) mm Hg) than in the control model (39.2 (33.7-49.6) mm Hg). The mean integral of the urethral pressure and urethral length was also significantly greater in the reconstruction model than in the control mod-el. Furthermore, sphincter tightening was enhanced by the electrical stimulation of the flap. Conclusions: Our results support our hypothesis that the functional reconstruction of urethral sphincters using muscle flaps is promising for the treatment of urinary incontinence.
AB - Introduction: The use of artificial urinary sphincters can improve urinary incontinence after radical prostatectomies; however, complications can arise. We hypothesized that dynamic graciloplasty improves urethral sphincter reconstruction. Materials and Methods: Models of urethral sphincter muscle reconstruction were developed in 5 adult rabbits by wrapping the gracilis muscle flap around the urethra. Intraurethral pressure was measured in each of the models before reconstruction (control), after reconstruction, and after electrical stimulation of the flap in reconstructed models (stimulated models). Results: The mean maximum urethral closure pressure was significantly greater in the reconstruction model (69.7 (66.5-115.8) mm Hg) than in the control model (39.2 (33.7-49.6) mm Hg). The mean integral of the urethral pressure and urethral length was also significantly greater in the reconstruction model than in the control mod-el. Furthermore, sphincter tightening was enhanced by the electrical stimulation of the flap. Conclusions: Our results support our hypothesis that the functional reconstruction of urethral sphincters using muscle flaps is promising for the treatment of urinary incontinence.
KW - Dynamic graciloplasty
KW - Nerve anastomosis
KW - Pudendal nerve
KW - Urethral sphincter incompetence
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UR - http://www.scopus.com/inward/citedby.url?scp=84959164224&partnerID=8YFLogxK
U2 - 10.1159/000442474
DO - 10.1159/000442474
M3 - Article
C2 - 26696007
AN - SCOPUS:84959164224
VL - 96
SP - 217
EP - 222
JO - Urologia Internationalis
JF - Urologia Internationalis
SN - 0042-1138
IS - 2
ER -