Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation

Rie Yamazaki, Hideki Nakasone, Hidenori Wada, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Kiriko Terasako, Misato Kikuchi, Shun ichi Kimura, Shinya Okuda, Shinichi Kako, Yukie Tanaka, Aki Tanihara, Kumi Oshima, Junji Nishida, Yoshinobu Kanda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed by leukemic transformation after cord blood transplantation for MDS with MG. Interestingly, MG reappeared before development of donor-derived MDS. We analyzed the immunoglobulin allotype gene polymorphisms to determine whether the MG after cord blood transplantation was of recipient origin or donor origin. Results of genetic analysis and enzyme-linked immunosorbent assay of IgG1 allotype revealed that the MG after cord blood transplantation was of donor origin. Although the mechanism of donor-derived MG remains unclear, the persistent presence of recipient's antigen presenting cells might have induced the abnormal immunoglobulin production.

Original languageEnglish
Pages (from-to)1119-1123
Number of pages5
JournalExperimental Hematology
Volume39
Issue number12
DOIs
Publication statusPublished - 2011 Dec 1
Externally publishedYes

Fingerprint

Cord Blood Stem Cell Transplantation
Paraproteinemias
Myelodysplastic Syndromes
Tissue Donors
Recurrence
Fetal Blood
Transplantation
Immunoglobulin Allotypes
Hypergammaglobulinemia
Immunoglobulin Genes
Antigen-Presenting Cells
Immunoglobulins
B-Lymphocytes
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Hematology

Cite this

Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation. / Yamazaki, Rie; Nakasone, Hideki; Wada, Hidenori; Sakamoto, Kana; Ashizawa, Masahiro; Sato, Miki; Terasako, Kiriko; Kikuchi, Misato; Kimura, Shun ichi; Okuda, Shinya; Kako, Shinichi; Tanaka, Yukie; Tanihara, Aki; Oshima, Kumi; Nishida, Junji; Kanda, Yoshinobu.

In: Experimental Hematology, Vol. 39, No. 12, 01.12.2011, p. 1119-1123.

Research output: Contribution to journalArticle

Yamazaki, R, Nakasone, H, Wada, H, Sakamoto, K, Ashizawa, M, Sato, M, Terasako, K, Kikuchi, M, Kimura, SI, Okuda, S, Kako, S, Tanaka, Y, Tanihara, A, Oshima, K, Nishida, J & Kanda, Y 2011, 'Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation', Experimental Hematology, vol. 39, no. 12, pp. 1119-1123. https://doi.org/10.1016/j.exphem.2011.09.002
Yamazaki, Rie ; Nakasone, Hideki ; Wada, Hidenori ; Sakamoto, Kana ; Ashizawa, Masahiro ; Sato, Miki ; Terasako, Kiriko ; Kikuchi, Misato ; Kimura, Shun ichi ; Okuda, Shinya ; Kako, Shinichi ; Tanaka, Yukie ; Tanihara, Aki ; Oshima, Kumi ; Nishida, Junji ; Kanda, Yoshinobu. / Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation. In: Experimental Hematology. 2011 ; Vol. 39, No. 12. pp. 1119-1123.
@article{422d89849ba4451a8d99c800f8c1074a,
title = "Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation",
abstract = "Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed by leukemic transformation after cord blood transplantation for MDS with MG. Interestingly, MG reappeared before development of donor-derived MDS. We analyzed the immunoglobulin allotype gene polymorphisms to determine whether the MG after cord blood transplantation was of recipient origin or donor origin. Results of genetic analysis and enzyme-linked immunosorbent assay of IgG1 allotype revealed that the MG after cord blood transplantation was of donor origin. Although the mechanism of donor-derived MG remains unclear, the persistent presence of recipient's antigen presenting cells might have induced the abnormal immunoglobulin production.",
author = "Rie Yamazaki and Hideki Nakasone and Hidenori Wada and Kana Sakamoto and Masahiro Ashizawa and Miki Sato and Kiriko Terasako and Misato Kikuchi and Kimura, {Shun ichi} and Shinya Okuda and Shinichi Kako and Yukie Tanaka and Aki Tanihara and Kumi Oshima and Junji Nishida and Yoshinobu Kanda",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.exphem.2011.09.002",
language = "English",
volume = "39",
pages = "1119--1123",
journal = "Experimental Hematology",
issn = "0301-472X",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation

AU - Yamazaki, Rie

AU - Nakasone, Hideki

AU - Wada, Hidenori

AU - Sakamoto, Kana

AU - Ashizawa, Masahiro

AU - Sato, Miki

AU - Terasako, Kiriko

AU - Kikuchi, Misato

AU - Kimura, Shun ichi

AU - Okuda, Shinya

AU - Kako, Shinichi

AU - Tanaka, Yukie

AU - Tanihara, Aki

AU - Oshima, Kumi

AU - Nishida, Junji

AU - Kanda, Yoshinobu

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed by leukemic transformation after cord blood transplantation for MDS with MG. Interestingly, MG reappeared before development of donor-derived MDS. We analyzed the immunoglobulin allotype gene polymorphisms to determine whether the MG after cord blood transplantation was of recipient origin or donor origin. Results of genetic analysis and enzyme-linked immunosorbent assay of IgG1 allotype revealed that the MG after cord blood transplantation was of donor origin. Although the mechanism of donor-derived MG remains unclear, the persistent presence of recipient's antigen presenting cells might have induced the abnormal immunoglobulin production.

AB - Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed by leukemic transformation after cord blood transplantation for MDS with MG. Interestingly, MG reappeared before development of donor-derived MDS. We analyzed the immunoglobulin allotype gene polymorphisms to determine whether the MG after cord blood transplantation was of recipient origin or donor origin. Results of genetic analysis and enzyme-linked immunosorbent assay of IgG1 allotype revealed that the MG after cord blood transplantation was of donor origin. Although the mechanism of donor-derived MG remains unclear, the persistent presence of recipient's antigen presenting cells might have induced the abnormal immunoglobulin production.

UR - http://www.scopus.com/inward/record.url?scp=81155123037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81155123037&partnerID=8YFLogxK

U2 - 10.1016/j.exphem.2011.09.002

DO - 10.1016/j.exphem.2011.09.002

M3 - Article

VL - 39

SP - 1119

EP - 1123

JO - Experimental Hematology

JF - Experimental Hematology

SN - 0301-472X

IS - 12

ER -