Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations

S. Nagafuchi, K. Umene, F. Yamanaka, S. Oohashi, M. Shindo, H. Kurisaki, J. Kudoh, N. Shimizu, T. Hara, M. Harada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) has characteristic clinical features with organ-specific autoimmune polyendocrine diseases and candidiasis, caused by the mutations of autoimmune regulator (AIRE) gene. Although almost all patients are complicated with mucocutaneous candidiasis, no apparent susceptibility to other infections has yet been reported. We herein report that a patient with APECED suffered from recurrent herpes simplex virus type 1 (HSV-1) infection after severe primary herpetic stomatitis, associated with sequential HSV-1 isolates of the same genomic profile, consistent with endogeneous recurrence. Thus, not only candidiasis but also HSV infection should receive more attention in patients with APECED, with treatment being administered accordingly.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalJournal of Internal Medicine
Volume261
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1

Keywords

  • Autoimmune polyendocrine syndrome type 1
  • Autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy
  • Autoimmune regulator
  • Candida
  • Herpes simplex virus

ASJC Scopus subject areas

  • Internal Medicine

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