Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations

S. Nagafuchi, K. Umene, F. Yamanaka, S. Oohashi, M. Shindo, H. Kurisaki, Jun Kudo, N. Shimizu, T. Hara, M. Harada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) has characteristic clinical features with organ-specific autoimmune polyendocrine diseases and candidiasis, caused by the mutations of autoimmune regulator (AIRE) gene. Although almost all patients are complicated with mucocutaneous candidiasis, no apparent susceptibility to other infections has yet been reported. We herein report that a patient with APECED suffered from recurrent herpes simplex virus type 1 (HSV-1) infection after severe primary herpetic stomatitis, associated with sequential HSV-1 isolates of the same genomic profile, consistent with endogeneous recurrence. Thus, not only candidiasis but also HSV infection should receive more attention in patients with APECED, with treatment being administered accordingly.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalJournal of Internal Medicine
Volume261
Issue number6
DOIs
Publication statusPublished - 2007 Jun

Fingerprint

Autoimmune Polyendocrinopathies
Candidiasis
Virus Diseases
Simplexvirus
Regulator Genes
Human Herpesvirus 1
Mutation
Herpetic Stomatitis
Infection
Autoimmune Diseases
Recurrence
Therapeutics

Keywords

  • Autoimmune polyendocrine syndrome type 1
  • Autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy
  • Autoimmune regulator
  • Candida
  • Herpes simplex virus

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations. / Nagafuchi, S.; Umene, K.; Yamanaka, F.; Oohashi, S.; Shindo, M.; Kurisaki, H.; Kudo, Jun; Shimizu, N.; Hara, T.; Harada, M.

In: Journal of Internal Medicine, Vol. 261, No. 6, 06.2007, p. 605-610.

Research output: Contribution to journalArticle

Nagafuchi, S. ; Umene, K. ; Yamanaka, F. ; Oohashi, S. ; Shindo, M. ; Kurisaki, H. ; Kudo, Jun ; Shimizu, N. ; Hara, T. ; Harada, M. / Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations. In: Journal of Internal Medicine. 2007 ; Vol. 261, No. 6. pp. 605-610.
@article{97f3c6e3eb244c638f50d5e8b7a8f221,
title = "Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations",
abstract = "Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) has characteristic clinical features with organ-specific autoimmune polyendocrine diseases and candidiasis, caused by the mutations of autoimmune regulator (AIRE) gene. Although almost all patients are complicated with mucocutaneous candidiasis, no apparent susceptibility to other infections has yet been reported. We herein report that a patient with APECED suffered from recurrent herpes simplex virus type 1 (HSV-1) infection after severe primary herpetic stomatitis, associated with sequential HSV-1 isolates of the same genomic profile, consistent with endogeneous recurrence. Thus, not only candidiasis but also HSV infection should receive more attention in patients with APECED, with treatment being administered accordingly.",
keywords = "Autoimmune polyendocrine syndrome type 1, Autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy, Autoimmune regulator, Candida, Herpes simplex virus",
author = "S. Nagafuchi and K. Umene and F. Yamanaka and S. Oohashi and M. Shindo and H. Kurisaki and Jun Kudo and N. Shimizu and T. Hara and M. Harada",
year = "2007",
month = "6",
doi = "10.1111/j.1365-2796.2007.01786.x",
language = "English",
volume = "261",
pages = "605--610",
journal = "Journal of Internal Medicine",
issn = "0954-6820",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations

AU - Nagafuchi, S.

AU - Umene, K.

AU - Yamanaka, F.

AU - Oohashi, S.

AU - Shindo, M.

AU - Kurisaki, H.

AU - Kudo, Jun

AU - Shimizu, N.

AU - Hara, T.

AU - Harada, M.

PY - 2007/6

Y1 - 2007/6

N2 - Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) has characteristic clinical features with organ-specific autoimmune polyendocrine diseases and candidiasis, caused by the mutations of autoimmune regulator (AIRE) gene. Although almost all patients are complicated with mucocutaneous candidiasis, no apparent susceptibility to other infections has yet been reported. We herein report that a patient with APECED suffered from recurrent herpes simplex virus type 1 (HSV-1) infection after severe primary herpetic stomatitis, associated with sequential HSV-1 isolates of the same genomic profile, consistent with endogeneous recurrence. Thus, not only candidiasis but also HSV infection should receive more attention in patients with APECED, with treatment being administered accordingly.

AB - Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) has characteristic clinical features with organ-specific autoimmune polyendocrine diseases and candidiasis, caused by the mutations of autoimmune regulator (AIRE) gene. Although almost all patients are complicated with mucocutaneous candidiasis, no apparent susceptibility to other infections has yet been reported. We herein report that a patient with APECED suffered from recurrent herpes simplex virus type 1 (HSV-1) infection after severe primary herpetic stomatitis, associated with sequential HSV-1 isolates of the same genomic profile, consistent with endogeneous recurrence. Thus, not only candidiasis but also HSV infection should receive more attention in patients with APECED, with treatment being administered accordingly.

KW - Autoimmune polyendocrine syndrome type 1

KW - Autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy

KW - Autoimmune regulator

KW - Candida

KW - Herpes simplex virus

UR - http://www.scopus.com/inward/record.url?scp=34249672361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249672361&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2796.2007.01786.x

DO - 10.1111/j.1365-2796.2007.01786.x

M3 - Article

C2 - 17547716

AN - SCOPUS:34249672361

VL - 261

SP - 605

EP - 610

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

SN - 0954-6820

IS - 6

ER -