[Recurrent rectal cancer with multiple liver and lung metastases treated effectively with oxaliplatin and capecitabine plus bevacizumab chemotherapy-a case report].

Nobushige Yabe, Shinji Murai, Hirotomo Shimizu, Kenjiro Kitasato, Takahisa Yoshikawa, Ippei Oto, Junpei Nakadai, Hirotoshi Hasegawa, Yuukou Kitagawa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A 60-year-old woman receiving treatment for diabetes underwent laparoscopic-assisted low anterior resection and was diagnosed as having rectosigmoid cancer in January 2010( pSS, n2[ +], sM0 fStage IIIb, mutant-type K-ras). She refused adjuvant chemotherapy. In July, after surgery, chest-abdominal-pelvic computed tomography( CT) scans showed bilateral lobe multiple liver metastases and right lobe lung metastases. We recommended oxaliplatin and capecitabine (CapeOX) plus bevacizumab( BV) chemotherapy or surgery. The CapeOX plus BV regimen was initiated at the patient's request. After 8 cycles of chemotherapy, a partial response was observed in the metastatic liver tumors and stable disease was observed in the lung metastases. As hypertension appeared after 16 cycles of chemotherapy, we switched the treatment to CapeOX. After 10 cycles of CapeOX, the chemotherapy was changed to capecitabine at the patient's request owing to the development of grade 2 chronic peripheral neuropathy. Chest-abdominal-pelvic CT scans after 32 cycles of this regimen revealed shrinkage of the multiple liver metastases. The patient has been receiving treatment as an outpatient. Surgical resection should be considered for patients with initially unresectable colon cancer with liver and/or lung metastases if systemic chemotherapy is effective.

Original languageEnglish
Title of host publicationGan to kagaku ryoho. Cancer & chemotherapy
Pages1834-1836
Number of pages3
Volume40
Edition12
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

oxaliplatin
Rectal Neoplasms
Neoplasm Metastasis
Drug Therapy
Lung
Liver
Thorax
Tomography
Peripheral Nervous System Diseases
Adjuvant Chemotherapy
Liver Neoplasms
Colonic Neoplasms
Lung Neoplasms
Neoplasms
Outpatients
Therapeutics
Capecitabine
Bevacizumab
Hypertension

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yabe, N., Murai, S., Shimizu, H., Kitasato, K., Yoshikawa, T., Oto, I., ... Kitagawa, Y. (2013). [Recurrent rectal cancer with multiple liver and lung metastases treated effectively with oxaliplatin and capecitabine plus bevacizumab chemotherapy-a case report]. In Gan to kagaku ryoho. Cancer & chemotherapy (12 ed., Vol. 40, pp. 1834-1836)

[Recurrent rectal cancer with multiple liver and lung metastases treated effectively with oxaliplatin and capecitabine plus bevacizumab chemotherapy-a case report]. / Yabe, Nobushige; Murai, Shinji; Shimizu, Hirotomo; Kitasato, Kenjiro; Yoshikawa, Takahisa; Oto, Ippei; Nakadai, Junpei; Hasegawa, Hirotoshi; Kitagawa, Yuukou.

Gan to kagaku ryoho. Cancer & chemotherapy. Vol. 40 12. ed. 2013. p. 1834-1836.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yabe, N, Murai, S, Shimizu, H, Kitasato, K, Yoshikawa, T, Oto, I, Nakadai, J, Hasegawa, H & Kitagawa, Y 2013, [Recurrent rectal cancer with multiple liver and lung metastases treated effectively with oxaliplatin and capecitabine plus bevacizumab chemotherapy-a case report]. in Gan to kagaku ryoho. Cancer & chemotherapy. 12 edn, vol. 40, pp. 1834-1836.
Yabe N, Murai S, Shimizu H, Kitasato K, Yoshikawa T, Oto I et al. [Recurrent rectal cancer with multiple liver and lung metastases treated effectively with oxaliplatin and capecitabine plus bevacizumab chemotherapy-a case report]. In Gan to kagaku ryoho. Cancer & chemotherapy. 12 ed. Vol. 40. 2013. p. 1834-1836
Yabe, Nobushige ; Murai, Shinji ; Shimizu, Hirotomo ; Kitasato, Kenjiro ; Yoshikawa, Takahisa ; Oto, Ippei ; Nakadai, Junpei ; Hasegawa, Hirotoshi ; Kitagawa, Yuukou. / [Recurrent rectal cancer with multiple liver and lung metastases treated effectively with oxaliplatin and capecitabine plus bevacizumab chemotherapy-a case report]. Gan to kagaku ryoho. Cancer & chemotherapy. Vol. 40 12. ed. 2013. pp. 1834-1836
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AU - Kitasato, Kenjiro

AU - Yoshikawa, Takahisa

AU - Oto, Ippei

AU - Nakadai, Junpei

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