Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer

Akira Ogasawara, Mako Kamiya, Kei Sakamoto, Yugo Kuriki, Kyohhei Fujita, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Haruna Onoyama, Hiroyuki Abe, Yosuke Tsuji, Mitsuhiro Fujishiro, Kazuhiko Koike, Masashi Fukayama, Yasuyuki Seto, Yasuteru Urano

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We have developed an activatable red fluorescence probe for dipeptidylpeptidase-IV (DPP-IV) by precisely controlling the photoinduced electron transfer (PeT) process of a red fluorescent scaffold, SiR600. The developed probe exhibited an extremely low background signal and showed significant fluorescence activation upon reaction with DPP-IV, enabling sensitive detection of esophageal cancer in clinical specimens from cancer patients.

Original languageEnglish
Pages (from-to)1055-1060
Number of pages6
JournalBioconjugate Chemistry
Volume30
Issue number4
DOIs
Publication statusPublished - 2019 Apr 17
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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