Redox regulation of NF-κB activation

Distinct redox regulation between the cytoplasm and the nucleus

Yasuaki Kabe, Kozue Ando, Satoshi Hirao, Makoto Yoshida, Hiroshi Handa

Research output: Contribution to journalArticle

350 Citations (Scopus)

Abstract

Reduction/oxidation (redox) regulation mediates numerous cellular responses and contributes to several physiological diseases. The transcription factor nuclear factor κB (NF-κB) is known to be a redox-sensitive factor. NF-κB plays a central role in immune responses and inflammation, through regulation of the gene expression of a large number of cytokines and other immune response genes. NF-κB is trapped in the cytoplasm in stimulated cells and translocates into the nucleus in response to several stimuli, including oxidative stress. Reactive oxygen species enhance the signal transduction pathways for NF-κB activation in the cytoplasm and translocation into the nucleus. In contrast, the DNA binding activity of oxidized NF-κB is significantly diminished, and that activity is restored by reducing enzymes, such as thioredoxin or redox factor 1. This review describes the signal transduction pathways for NF-κB activation and redox regulation of NF-kB activation in the cytoplasm and nucleus.

Original languageEnglish
Pages (from-to)395-403
Number of pages9
JournalAntioxidants and Redox Signaling
Volume7
Issue number3-4
DOIs
Publication statusPublished - 2005 Mar
Externally publishedYes

Fingerprint

Oxidation-Reduction
Cytoplasm
Chemical activation
Oxidation
Signal transduction
Signal Transduction
Thioredoxins
NF-kappa B
Gene Expression Regulation
Oxidative stress
Reactive Oxygen Species
Oxidative Stress
Transcription Factors
Gene expression
Cytokines
Inflammation
Genes
DNA
Enzymes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Redox regulation of NF-κB activation : Distinct redox regulation between the cytoplasm and the nucleus. / Kabe, Yasuaki; Ando, Kozue; Hirao, Satoshi; Yoshida, Makoto; Handa, Hiroshi.

In: Antioxidants and Redox Signaling, Vol. 7, No. 3-4, 03.2005, p. 395-403.

Research output: Contribution to journalArticle

Kabe, Yasuaki ; Ando, Kozue ; Hirao, Satoshi ; Yoshida, Makoto ; Handa, Hiroshi. / Redox regulation of NF-κB activation : Distinct redox regulation between the cytoplasm and the nucleus. In: Antioxidants and Redox Signaling. 2005 ; Vol. 7, No. 3-4. pp. 395-403.
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