Redox regulation of NF-κB activation: Distinct redox regulation between the cytoplasm and the nucleus

Yasuaki Kabe, Kozue Ando, Satoshi Hirao, Makoto Yoshida, Hiroshi Handa

Research output: Contribution to journalReview article

377 Citations (Scopus)


Reduction/oxidation (redox) regulation mediates numerous cellular responses and contributes to several physiological diseases. The transcription factor nuclear factor κB (NF-κB) is known to be a redox-sensitive factor. NF-κB plays a central role in immune responses and inflammation, through regulation of the gene expression of a large number of cytokines and other immune response genes. NF-κB is trapped in the cytoplasm in stimulated cells and translocates into the nucleus in response to several stimuli, including oxidative stress. Reactive oxygen species enhance the signal transduction pathways for NF-κB activation in the cytoplasm and translocation into the nucleus. In contrast, the DNA binding activity of oxidized NF-κB is significantly diminished, and that activity is restored by reducing enzymes, such as thioredoxin or redox factor 1. This review describes the signal transduction pathways for NF-κB activation and redox regulation of NF-kB activation in the cytoplasm and nucleus.

Original languageEnglish
Pages (from-to)395-403
Number of pages9
JournalAntioxidants and Redox Signaling
Issue number3-4
Publication statusPublished - 2005 Mar 1
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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