Reduced-dose (Two-thirds) R-CHOP chemotherapy for elderly patients with non- hodgkin lymphoma

Misato Kikuchi, Hideki Nakasone, Yu Akahoshi, Hirofumi Nakano, Tomotaka Ugai, Hidenori Wada, Ryoko Yamasaki, Kana Sakamoto, Koji Kawamura, Yuko Ishihara, Miki Sato, Masahiro Ashizawa, Kiriko Terasako-Saito, Shun Ichi Kimura, Rie Yamazaki, Shinichi Kako, Junya Kanda, Junji Nishida, Naohiro Sekiguchi, Satoshi NotoMichiko Kida, Akira Hangaishi, Kensuke Usuki, Yoshinobu Kanda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Elderly patients with non-Hodgkin lymphoma (NHL) have a poor prognosis. Owing to treatment-related toxicities, there is no standard chemotherapy for the elderly patients, especially those aged 70 years or older. In this study, we retrospectively evaluated the efficacy and toxicity of reduced-dose (two-thirds) R-CHOP chemotherapy as an initial chemotherapy for 45 patients aged 70 years or older with B-cell NHL. The WHO classification of NHL included diffuse large B-cell lymphoma (DLBCL) (31), mantle cell lymphoma (5), follicular lymphoma (4), extranodal marginal zone lymphoma (1), Burkitt lymphoma (1), and B-cell lymphoma whose further types were unclassified (3). The incidences of grade 4 neutropenia and febrile neutropenia (FN) were 51.1 and 15.6%, respectively. Efficacy was evaluated in patients with DLBCL. The overall and complete response (CR) rates were 96.7 and 90.0%, respectively. Two-year event-free survival (EFS) and overall survival (OS) were 84.4 and 89.2%, respectively. There was no treatment-related mortality. In conclusion, two-thirds R-CHOP chemotherapy is a promising treatment for elderly patients with B-cell NHL in terms of its efficacy and toxicity.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalJournal of Chemotherapy
Volume27
Issue number2
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Diffuse large B-cell lymphoma
  • Elderly patients
  • Neutropenia
  • Non-Hodgkin lymphoma
  • R-CHOP
  • Relative dose intensity
  • Rituximab

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Kikuchi, M., Nakasone, H., Akahoshi, Y., Nakano, H., Ugai, T., Wada, H., Yamasaki, R., Sakamoto, K., Kawamura, K., Ishihara, Y., Sato, M., Ashizawa, M., Terasako-Saito, K., Kimura, S. I., Yamazaki, R., Kako, S., Kanda, J., Nishida, J., Sekiguchi, N., ... Kanda, Y. (2015). Reduced-dose (Two-thirds) R-CHOP chemotherapy for elderly patients with non- hodgkin lymphoma. Journal of Chemotherapy, 27(2), 99-105. https://doi.org/10.1179/1973947814Y.0000000219