Reduced expression of αvβ3 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures: Improvement by danazol treatment

Chisei Tei, Tetsuo Maruyama, Naoaki Kuji, Toyohiko Miyazaki, Mikio Mikami, Yasunori Yoshimura

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose: To determine whether there is any association between the expression of endometrial integrin αvβ3 and repeated IVF-ET failure and to examine the effect of danazol treatment on αvβ3 expression. Methods: This prospective study was performed using a semiquantitative immunohistochemical analysis on the staining intensity of αvβ3 in the mid-secretory endometria derived from 10 fertile women and 57 infertile patients with a history of repeated IVF-ET failures. Nine patients randomly selected from these 22 patients with unexplained infertility were then treated with oral danazol administration for 12 weeks and reexamined at the first mid-secretory phase after the danazol treatment. Result(s): The levels of endometrial αvβ3 expression were lower in 22 patients with unexplained infertility than in the fertile control and 35 patients with explained infertility. The 9 patients treated with danazol showed a significant increase in the αvβ3 staining. Conclusion(s): The significantly decreased expression of endometrial integrin αvβ3 suggested that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility. Danazol may have a therapeutic potential in improving endometrial function together with up-regulation of αvβ3.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalJournal of Assisted Reproduction and Genetics
Volume20
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1

Fingerprint

Danazol
Endometrium
Integrins
Infertility
Therapeutics
Staining and Labeling
Oral Administration
Up-Regulation
Prospective Studies

Keywords

  • Danazol
  • Implantation failure
  • Integrin αvβ3
  • IVF-ET
  • Unexplained infertility

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics
  • Reproductive Medicine

Cite this

Reduced expression of αvβ3 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures : Improvement by danazol treatment. / Tei, Chisei; Maruyama, Tetsuo; Kuji, Naoaki; Miyazaki, Toyohiko; Mikami, Mikio; Yoshimura, Yasunori.

In: Journal of Assisted Reproduction and Genetics, Vol. 20, No. 1, 01.01.2003, p. 13-20.

Research output: Contribution to journalArticle

@article{dbd8c3a7e4574f528618b9b28af1ea26,
title = "Reduced expression of αvβ3 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures: Improvement by danazol treatment",
abstract = "Purpose: To determine whether there is any association between the expression of endometrial integrin αvβ3 and repeated IVF-ET failure and to examine the effect of danazol treatment on αvβ3 expression. Methods: This prospective study was performed using a semiquantitative immunohistochemical analysis on the staining intensity of αvβ3 in the mid-secretory endometria derived from 10 fertile women and 57 infertile patients with a history of repeated IVF-ET failures. Nine patients randomly selected from these 22 patients with unexplained infertility were then treated with oral danazol administration for 12 weeks and reexamined at the first mid-secretory phase after the danazol treatment. Result(s): The levels of endometrial αvβ3 expression were lower in 22 patients with unexplained infertility than in the fertile control and 35 patients with explained infertility. The 9 patients treated with danazol showed a significant increase in the αvβ3 staining. Conclusion(s): The significantly decreased expression of endometrial integrin αvβ3 suggested that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility. Danazol may have a therapeutic potential in improving endometrial function together with up-regulation of αvβ3.",
keywords = "Danazol, Implantation failure, Integrin αvβ3, IVF-ET, Unexplained infertility",
author = "Chisei Tei and Tetsuo Maruyama and Naoaki Kuji and Toyohiko Miyazaki and Mikio Mikami and Yasunori Yoshimura",
year = "2003",
month = "1",
day = "1",
doi = "10.1023/A:1021254620888",
language = "English",
volume = "20",
pages = "13--20",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Reduced expression of αvβ3 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures

T2 - Improvement by danazol treatment

AU - Tei, Chisei

AU - Maruyama, Tetsuo

AU - Kuji, Naoaki

AU - Miyazaki, Toyohiko

AU - Mikami, Mikio

AU - Yoshimura, Yasunori

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Purpose: To determine whether there is any association between the expression of endometrial integrin αvβ3 and repeated IVF-ET failure and to examine the effect of danazol treatment on αvβ3 expression. Methods: This prospective study was performed using a semiquantitative immunohistochemical analysis on the staining intensity of αvβ3 in the mid-secretory endometria derived from 10 fertile women and 57 infertile patients with a history of repeated IVF-ET failures. Nine patients randomly selected from these 22 patients with unexplained infertility were then treated with oral danazol administration for 12 weeks and reexamined at the first mid-secretory phase after the danazol treatment. Result(s): The levels of endometrial αvβ3 expression were lower in 22 patients with unexplained infertility than in the fertile control and 35 patients with explained infertility. The 9 patients treated with danazol showed a significant increase in the αvβ3 staining. Conclusion(s): The significantly decreased expression of endometrial integrin αvβ3 suggested that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility. Danazol may have a therapeutic potential in improving endometrial function together with up-regulation of αvβ3.

AB - Purpose: To determine whether there is any association between the expression of endometrial integrin αvβ3 and repeated IVF-ET failure and to examine the effect of danazol treatment on αvβ3 expression. Methods: This prospective study was performed using a semiquantitative immunohistochemical analysis on the staining intensity of αvβ3 in the mid-secretory endometria derived from 10 fertile women and 57 infertile patients with a history of repeated IVF-ET failures. Nine patients randomly selected from these 22 patients with unexplained infertility were then treated with oral danazol administration for 12 weeks and reexamined at the first mid-secretory phase after the danazol treatment. Result(s): The levels of endometrial αvβ3 expression were lower in 22 patients with unexplained infertility than in the fertile control and 35 patients with explained infertility. The 9 patients treated with danazol showed a significant increase in the αvβ3 staining. Conclusion(s): The significantly decreased expression of endometrial integrin αvβ3 suggested that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility. Danazol may have a therapeutic potential in improving endometrial function together with up-regulation of αvβ3.

KW - Danazol

KW - Implantation failure

KW - Integrin αvβ3

KW - IVF-ET

KW - Unexplained infertility

UR - http://www.scopus.com/inward/record.url?scp=0037277627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037277627&partnerID=8YFLogxK

U2 - 10.1023/A:1021254620888

DO - 10.1023/A:1021254620888

M3 - Article

C2 - 12645863

AN - SCOPUS:0037277627

VL - 20

SP - 13

EP - 20

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

IS - 1

ER -