Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma

Masaaki Takamura, Takafumi Ichida, Yasunobu Matsuda, Masaaki Kobayashi, Satoshi Yamagiwa, Takuya Genda, Kazuhiko Shioji, Satoru Hashimoto, Minoru Nomoto, Katsuyoshi Hatakeyama, Yoichi Ajioka, Michiie Sakamoto, Setsuo Hirohashi, Yutaka Aoyagi

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Liver-intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade (P=0.015), lymphatic invasion (P=0.033), lymph node metastasis (P=0.015), and an advanced pTNM stage (P=0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalCancer Letters
Volume212
Issue number2
DOIs
Publication statusPublished - 2004 Aug 30

Keywords

  • Colorectal carcinoma
  • Immunohistochemistry
  • Liver-intestine cadherin
  • Lymph node metastasis
  • monoclonal antibody

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Takamura, M., Ichida, T., Matsuda, Y., Kobayashi, M., Yamagiwa, S., Genda, T., Shioji, K., Hashimoto, S., Nomoto, M., Hatakeyama, K., Ajioka, Y., Sakamoto, M., Hirohashi, S., & Aoyagi, Y. (2004). Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. Cancer Letters, 212(2), 253-259. https://doi.org/10.1016/j.canlet.2004.03.016