Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma

Masaaki Takamura; Takafumi Ichida; Yasunobu Matsuda; Masaaki Kobayashi; Satoshi Yamagiwa; Takuya Genda; Kazuhiko Shioji; Satoru Hashimoto; Minoru Nomoto; Katsuyoshi Hatakeyama; Yoichi Ajioka; Michiie Sakamoto; Setsuo Hirohashi; Yutaka Aoyagi

doi:10.1016/j.canlet.2004.03.016

Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma

Masaaki Takamura, Takafumi Ichida, Yasunobu Matsuda, Masaaki Kobayashi, Satoshi Yamagiwa, Takuya Genda, Kazuhiko Shioji, Satoru Hashimoto, Minoru Nomoto, Katsuyoshi Hatakeyama, Yoichi Ajioka, Michiie Sakamoto, Setsuo Hirohashi, Yutaka Aoyagi

Department of Pathology

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Liver-intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade (P=0.015), lymphatic invasion (P=0.033), lymph node metastasis (P=0.015), and an advanced pTNM stage (P=0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.

Original language	English
Pages (from-to)	253-259
Number of pages	7
Journal	Cancer Letters
Volume	212
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2004.03.016
Publication status	Published - 2004 Aug 30

Keywords

Colorectal carcinoma
Immunohistochemistry
Liver-intestine cadherin
Lymph node metastasis
monoclonal antibody

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.canlet.2004.03.016

Cite this

Takamura, M., Ichida, T., Matsuda, Y., Kobayashi, M., Yamagiwa, S., Genda, T., Shioji, K., Hashimoto, S., Nomoto, M., Hatakeyama, K., Ajioka, Y., Sakamoto, M., Hirohashi, S., & Aoyagi, Y. (2004). Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. Cancer Letters, 212(2), 253-259. https://doi.org/10.1016/j.canlet.2004.03.016

Takamura, M, Ichida, T, Matsuda, Y, Kobayashi, M, Yamagiwa, S, Genda, T, Shioji, K, Hashimoto, S, Nomoto, M, Hatakeyama, K, Ajioka, Y, Sakamoto, M, Hirohashi, S & Aoyagi, Y 2004, 'Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma', Cancer Letters, vol. 212, no. 2, pp. 253-259. https://doi.org/10.1016/j.canlet.2004.03.016

@article{127f320b77d34d959e6bdbd470b53915,

title = "Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma",

abstract = "Liver-intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade (P=0.015), lymphatic invasion (P=0.033), lymph node metastasis (P=0.015), and an advanced pTNM stage (P=0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.",

keywords = "Colorectal carcinoma, Immunohistochemistry, Liver-intestine cadherin, Lymph node metastasis, monoclonal antibody",

author = "Masaaki Takamura and Takafumi Ichida and Yasunobu Matsuda and Masaaki Kobayashi and Satoshi Yamagiwa and Takuya Genda and Kazuhiko Shioji and Satoru Hashimoto and Minoru Nomoto and Katsuyoshi Hatakeyama and Yoichi Ajioka and Michiie Sakamoto and Setsuo Hirohashi and Yutaka Aoyagi",

year = "2004",

month = aug,

day = "30",

doi = "10.1016/j.canlet.2004.03.016",

language = "English",

volume = "212",

pages = "253--259",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma

AU - Takamura, Masaaki

AU - Ichida, Takafumi

AU - Matsuda, Yasunobu

AU - Kobayashi, Masaaki

AU - Yamagiwa, Satoshi

AU - Genda, Takuya

AU - Shioji, Kazuhiko

AU - Hashimoto, Satoru

AU - Nomoto, Minoru

AU - Hatakeyama, Katsuyoshi

AU - Ajioka, Yoichi

AU - Sakamoto, Michiie

AU - Hirohashi, Setsuo

AU - Aoyagi, Yutaka

PY - 2004/8/30

Y1 - 2004/8/30

N2 - Liver-intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade (P=0.015), lymphatic invasion (P=0.033), lymph node metastasis (P=0.015), and an advanced pTNM stage (P=0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.

AB - Liver-intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade (P=0.015), lymphatic invasion (P=0.033), lymph node metastasis (P=0.015), and an advanced pTNM stage (P=0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.

KW - Colorectal carcinoma

KW - Immunohistochemistry

KW - Liver-intestine cadherin

KW - Lymph node metastasis

KW - monoclonal antibody

UR - http://www.scopus.com/inward/record.url?scp=3242886110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242886110&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2004.03.016

DO - 10.1016/j.canlet.2004.03.016

M3 - Article

C2 - 15279905

AN - SCOPUS:3242886110

SN - 0304-3835

VL - 212

SP - 253

EP - 259

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this