Reduced-intensity stem cell transplantation from an HLA-identical sibling donor in patients with myeloid malignancies

T. Hamaki, M. Kami, S. W. Kim, Y. Onishi, Y. Kishi, N. Murashige, A. Hori, R. Kojima, M. Sakiyama, O. Imataki, Y. Heike, R. Tanosaki, S. Masuo, S. Miyakoshi, S. Taniguchi, K. Tobinai, Y. Takaue

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the feasibility and efficacy of allogeneic hematopoietic stem cell transplantation with a reduced-intensity regimen (RIST) in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). In all, 36 patients (median age 55 years) underwent RIST from an HLA-matched related donor between September 1999 and December 2002. The diagnoses included AML (n = 14), leukemia evolving from MDS (n = 10), and MDS (refractory anemia with excess blasts n = 6, refractory anemia n = 6). The RIST regimen consisted of purine analog (cladribine or fludarabine)/busulfan, with or without antithymocyte globulin. The regimen was well tolerated, and 34 patients achieved durable engraftment and most achieved remission after RIST. A total of 17 patients developed grade II-IV acute GVHD, and 27 developed chronic GVHD. Eight patients relapsed, and five of them received antithymocyte globulin (ATG) as part of the preparative regimen. A total of 12 patients died (four disease progression, six transplantation-related complications, and two others). Estimated 1-year disease-free survival (DFS) in low- and high-risk groups was 85 and 64%, respectively. We conclude that RIST can be performed safely in elderly patients with myeloid malignancies, and has therapeutic potential for those who fail conventional chemotherapy. In view of the significant association between GVHD or ATG and DFS, defined management of GVHD following RIST should become a major target of clinical research.

Original languageEnglish
Pages (from-to)891-900
Number of pages10
JournalBone Marrow Transplantation
Volume33
Issue number9
DOIs
Publication statusPublished - 2004 May 1
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Graft-versus-host disease
  • Graft-versus-leukemia effect
  • Myelodysplastic syndrome
  • Reduced-intensity hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Reduced-intensity stem cell transplantation from an HLA-identical sibling donor in patients with myeloid malignancies'. Together they form a unique fingerprint.

  • Cite this

    Hamaki, T., Kami, M., Kim, S. W., Onishi, Y., Kishi, Y., Murashige, N., Hori, A., Kojima, R., Sakiyama, M., Imataki, O., Heike, Y., Tanosaki, R., Masuo, S., Miyakoshi, S., Taniguchi, S., Tobinai, K., & Takaue, Y. (2004). Reduced-intensity stem cell transplantation from an HLA-identical sibling donor in patients with myeloid malignancies. Bone Marrow Transplantation, 33(9), 891-900. https://doi.org/10.1038/sj.bmt.1704477