Reduced Nogo-P3 in adults with developmental coordination disorder (DCD)

Kota Suzuki, Yosuke Kita, Yuka Shirakawa, Yuka Egashira, Shota Mitsuhashi, Yuzuki Kitamura, Hideyuki Okuzumi, Yoshimi Kaga, Masumi Inagaki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Nogo-N2 is associated with the premotor cognitive process that precedes motor response (e.g., conflict monitoring), whereas Nogo-P3 is related to the inhibition of the actual motor response. We examined the influence of motor clumsiness of developmental coordination disorder (DCD) on components of the event-related potential in a Go/Nogo task. Participants were healthy adults (N = 81) that were classified into control and DCD groups based on the Movement Assessment Battery for Children Second Edition. We manipulated the difficulty in stopping a response by varying the frequency of Nogo stimuli in a response task into rare (20%) and frequent (80%) conditions, and Nogo-N2 and Nogo-P3 were calculated from electroencephalograms (EEGs) during the Go/Nogo tasks. The commission error rate in the rare condition was significantly higher in the DCD group than in the control group, indicating that motor clumsiness decreases task performance. There were no differences in Nogo-N2 between DCD and control groups. However, Nogo-P3 in the rare condition was reduced in the DCD group compared to the control group. These results suggest that the influence of motor clumsiness is limited to the cognitive process after the initiation of the actual motor response.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalInternational Journal of Psychophysiology
Volume153
DOIs
Publication statusPublished - 2020 Jul
Externally publishedYes

Keywords

  • Cognitive control
  • Developmental coordination disorder
  • Event-related potentials
  • Inhibition
  • Motor clumsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)

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