Abstract
This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.
Original language | English |
---|---|
Pages (from-to) | 67-73 |
Number of pages | 7 |
Journal | Cancer Letters |
Volume | 132 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1998 Oct 23 |
Externally published | Yes |
Keywords
- Cell cycle regulation
- Cyclin-dependent kinase inhibitor
- Hepatocellular carcinoma
- p27(Kip1)
ASJC Scopus subject areas
- Oncology
- Cancer Research