Reduced p27(Kip1) expression in hepatocellular carcinomas

Ai Min Hui; Lin Sun; Yae Kanai; Michiie Sakamoto; Setsuo Hirohashi

doi:10.1016/S0304-3835(98)00164-5

Reduced p27(Kip1) expression in hepatocellular carcinomas

Ai Min Hui, Lin Sun, Yae Kanai, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	67-73
Number of pages	7
Journal	Cancer Letters
Volume	132
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3835(98)00164-5
Publication status	Published - 1998 Oct 23
Externally published	Yes

Keywords

Cell cycle regulation
Cyclin-dependent kinase inhibitor
Hepatocellular carcinoma
p27(Kip1)

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(98)00164-5

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title = "Reduced p27(Kip1) expression in hepatocellular carcinomas",

abstract = "This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.",

keywords = "Cell cycle regulation, Cyclin-dependent kinase inhibitor, Hepatocellular carcinoma, p27(Kip1)",

author = "Hui, {Ai Min} and Lin Sun and Yae Kanai and Michiie Sakamoto and Setsuo Hirohashi",

note = "Funding Information: This study was supported in part by a Grant-in-Aid for the 2nd-term Comprehensive 10-Year Strategy for Cancer Control and by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare of Japan. A.-M.H. was awarded a Domestic Research Fellowship from the Japan Science and Technology Corporation.",

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doi = "10.1016/S0304-3835(98)00164-5",

language = "English",

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AU - Hui, Ai Min

AU - Sun, Lin

AU - Kanai, Yae

AU - Sakamoto, Michiie

AU - Hirohashi, Setsuo

N1 - Funding Information: This study was supported in part by a Grant-in-Aid for the 2nd-term Comprehensive 10-Year Strategy for Cancer Control and by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare of Japan. A.-M.H. was awarded a Domestic Research Fellowship from the Japan Science and Technology Corporation.

PY - 1998/10/23

Y1 - 1998/10/23

N2 - This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.

AB - This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.

KW - Cell cycle regulation

KW - Cyclin-dependent kinase inhibitor

KW - Hepatocellular carcinoma

KW - p27(Kip1)

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Reduced p27(Kip1) expression in hepatocellular carcinomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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