Abstract
This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 67-73 |
| Number of pages | 7 |
| Journal | Cancer Letters |
| Volume | 132 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1998 Oct 23 |
| Externally published | Yes |
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Keywords
- Cell cycle regulation
- Cyclin-dependent kinase inhibitor
- Hepatocellular carcinoma
- p27(Kip1)
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Reduced p27(Kip1) expression in hepatocellular carcinomas. / Hui, Ai Min; Sun, Lin; Kanai, Yae; Sakamoto, Michiie; Hirohashi, Setsuo.
In: Cancer Letters, Vol. 132, No. 1-2, 23.10.1998, p. 67-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced p27(Kip1) expression in hepatocellular carcinomas
AU - Hui, Ai Min
AU - Sun, Lin
AU - Kanai, Yae
AU - Sakamoto, Michiie
AU - Hirohashi, Setsuo
PY - 1998/10/23
Y1 - 1998/10/23
N2 - This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.
AB - This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.
KW - Cell cycle regulation
KW - Cyclin-dependent kinase inhibitor
KW - Hepatocellular carcinoma
KW - p27(Kip1)
UR - http://www.scopus.com/inward/record.url?scp=0032561075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032561075&partnerID=8YFLogxK
U2 - 10.1016/S0304-3835(98)00164-5
DO - 10.1016/S0304-3835(98)00164-5
M3 - Article
C2 - 10397455
AN - SCOPUS:0032561075
VL - 132
SP - 67
EP - 73
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1-2
ER -