TY - JOUR
T1 - Reduction of Acyl Enolates of α-Substituted β-Keto Esters by Bakers' Yeast
AU - Ohta, Hiromichi
AU - Kobayashi, Naoki
AU - Sugai, Takeshi
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - Enol esters of 2-substituted-3-oxoalkanoates of (Z)-configuration were reduced by bakers' yeast to chiral 2-substituted-3-hydroxyalkanoates. The syn-selectivities of this reaction increased compared with those of the reduction of the corresponding racemic keto esters. The reaction may proceed via an asymmetric hydrolysis of the enol esters, followed by the reduction of the resulting carbonyl group.
AB - Enol esters of 2-substituted-3-oxoalkanoates of (Z)-configuration were reduced by bakers' yeast to chiral 2-substituted-3-hydroxyalkanoates. The syn-selectivities of this reaction increased compared with those of the reduction of the corresponding racemic keto esters. The reaction may proceed via an asymmetric hydrolysis of the enol esters, followed by the reduction of the resulting carbonyl group.
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U2 - 10.1271/bbb1961.54.489
DO - 10.1271/bbb1961.54.489
M3 - Article
C2 - 19130673
AN - SCOPUS:0000139123
SN - 0916-8451
VL - 54
SP - 489
EP - 493
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 2
ER -