Reduction of sodium intake by intracerebroventricular injection of brain natriuretic peptide (BNP) in salt-depleted rats

G. Shirakami, G. Nakao, T. Yamada, H. Itoh, A. Sugawara, Y. Saito, M. Mukoyama, H. Arai, K. Hosoda, S. I. Suga, K. Mori, H. Imura

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Abstract

In order to elucidate the role of brain natriuretic peptide (BNP) in the control of salt appetite, the effect of the intracerebroventricular (i.c.v.) injection of BNP on sodium intake in salt-depleted rats was examined with a free-choice, two-bottle preference test under conscious unrestrained conditions. Rats were offered two drinking bottles containing 0.30 M NaCl and distilled water. The i.c.v. injection of BNP attenuated the intake of 0.30 M NaCl dose-dependently. One-nmol BNP inhibited salt intake for 4 h, but not for 24 h. The inhibitory potency of BNP on salt appetite was comparable to that of atrial natriuretic polypeptide (ANP) simultaneously determined. It is concluded that salt appetite in sodium-depleted rats is blunted by centrally administered BNP as well as ANP.

Original languageEnglish
Pages (from-to)341-348
Number of pages8
JournalBiomedical Research
Volume10
Issue numberSUPPL. 3
Publication statusPublished - 1989 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Shirakami, G., Nakao, G., Yamada, T., Itoh, H., Sugawara, A., Saito, Y., Mukoyama, M., Arai, H., Hosoda, K., Suga, S. I., Mori, K., & Imura, H. (1989). Reduction of sodium intake by intracerebroventricular injection of brain natriuretic peptide (BNP) in salt-depleted rats. Biomedical Research, 10(SUPPL. 3), 341-348.