Reductive desymmetrization of 2-alkyl-1,3-diketones catalyzed by optically active β-ketoiminato cobalt complexes

Yuhki Ohtsuka, Kiichirou Koyasu, Taketo Ikeno, Tohru Yamada

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

(Equation presented) The reductive desymmetrization of acyclic 1,3-diketones was achieved for the first time by catalytic borohydride reduction in the presence of optically active β-ketoiminato cobalt(II) complex catalysts. In this reaction, various 2-substituted-1,3-diaryl-1,3-propanediones were converted into the corresponding optically active 2-substituted-1,3-diaryl-3-hydroxypropanone in good-to-high yields with excellent diastereo-and enantioselectivities and high catalytic efficiencies.

Original languageEnglish
Pages (from-to)2543-2546
Number of pages4
JournalOrganic Letters
Volume3
Issue number16
DOIs
Publication statusPublished - 2001 Aug 9

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Borohydrides
borohydrides
Enantioselectivity
Cobalt
cobalt
catalysts
Catalysts

ASJC Scopus subject areas

  • Molecular Medicine

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Reductive desymmetrization of 2-alkyl-1,3-diketones catalyzed by optically active β-ketoiminato cobalt complexes. / Ohtsuka, Yuhki; Koyasu, Kiichirou; Ikeno, Taketo; Yamada, Tohru.

In: Organic Letters, Vol. 3, No. 16, 09.08.2001, p. 2543-2546.

Research output: Contribution to journalArticle

Ohtsuka, Yuhki ; Koyasu, Kiichirou ; Ikeno, Taketo ; Yamada, Tohru. / Reductive desymmetrization of 2-alkyl-1,3-diketones catalyzed by optically active β-ketoiminato cobalt complexes. In: Organic Letters. 2001 ; Vol. 3, No. 16. pp. 2543-2546.
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AU - Yamada, Tohru

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