Reductive desymmetrization of 2-alkyl-1,3-diketones catalyzed by optically active β-ketoiminato cobalt complexes

Yuhki Ohtsuka, Kiichirou Koyasu, Taketo Ikeno, Tohru Yamada

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

(Equation presented) The reductive desymmetrization of acyclic 1,3-diketones was achieved for the first time by catalytic borohydride reduction in the presence of optically active β-ketoiminato cobalt(II) complex catalysts. In this reaction, various 2-substituted-1,3-diaryl-1,3-propanediones were converted into the corresponding optically active 2-substituted-1,3-diaryl-3-hydroxypropanone in good-to-high yields with excellent diastereo-and enantioselectivities and high catalytic efficiencies.

Original languageEnglish
Pages (from-to)2543-2546
Number of pages4
JournalOrganic Letters
Volume3
Issue number16
DOIs
Publication statusPublished - 2001 Aug 9

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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