Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits

Kazuhiro Ishii, Taku Nagai, Yuki Hirota, Mariko Noda, Toshitaka Nabeshima, Kiyofumi Yamada, Ken ichiro Kubo, Kazunori Nakajima

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Reelin has recently attracted attention because of its connection to several neuropsychiatric diseases. We previously reported the finding that prior transplantation of GABAergic neuron precursor cells into the medial prefrontal cortex (mPFC) of mice significantly prevented the induction of cognitive and sensory-motor gating deficits induced by phencyclidine (PCP). The majority of the precursor cells transplanted into the mPFC of the recipient mice differentiated into members of a somatostatin/Reelin-expressing class of GABAergic interneurons. These findings raised the possibility that Reelin secreted by the transplanted cells plays an important role in preventing the deficits induced by PCP. In this study, we investigated whether Reelin itself has a preventive effect on PCP-induced behavioral phenotypes by injecting conditioned medium containing Reelin into the lateral ventricle of the brains of 6- to 7-week-old male mice before administrating PCP. Behavioral analyses showed that the prior Reelin injection had a preventive effect against induction of the cognitive and sensory-motor gating deficits associated with PCP. Moreover, one of the types of Reelin receptor was found to be expressed by neurons in the mPFC. The results of this study point to the Reelin signaling pathway as a candidate target for the pharmacologic treatment of neuropsychiatric diseases.

Original languageEnglish
Pages (from-to)30-36
Number of pages7
JournalNeuroscience Research
Volume96
DOIs
Publication statusPublished - 2015 Jul 1

Keywords

  • Cognitive deficits
  • GABAergic interneuron
  • Phencyclidine
  • Reelin
  • Schizophrenia
  • Sonsory-motor gating deficits

ASJC Scopus subject areas

  • Neuroscience(all)

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