Abstract
This conference proceeding describes a rapid fabrication of hierarchical tissues with high cell density by cell fiber (Cell-F) assembling. We prepared cell-adhesive alginate fibers and cell-encapsulated fibers using with the same microfluidic device. Cells proliferated and connected within fibers, and cell fibers kept their fiber-shapes after removing alginate. Exposed cell fibers were reeled around cell-adhesive alginate (Alg-CoP) fiber with tweezers. These cell fibers easily adhered to Alg-CoP surfaces, and we succeeded in fabricating hierarchical thick tissues with 1×10<sup>8</sup> cells/cm<sup>3</sup> within 1 day. This approach would benefit for rapid fabrication of 3D tissue constructs with similar cell density to human body.
| Original language | English |
|---|---|
| Title of host publication | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1140-1141 |
| Number of pages | 2 |
| ISBN (Print) | 9780979806476 |
| Publication status | Published - 2014 |
| Externally published | Yes |
| Event | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 2014 Oct 26 → 2014 Oct 30 |
Other
| Other | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
|---|---|
| Country/Territory | United States |
| City | San Antonio |
| Period | 14/10/26 → 14/10/30 |
Keywords
- Cell fiber
- Hierarchical structure
- Tissue engineering
ASJC Scopus subject areas
- Control and Systems Engineering